Synthesis of new [1,2,3]triazoles and 1H-tetrazoles via reactions of 3,(5)-(Di)chloro-2H-1,4-(benz)oxazin-2-ones with diazocompounds or sodium azide
Sodium azide and diazocompounds react with (benz)oxazinones to give specifically substituted [1,2,3]triazoles and 1H-tetrazoles after lactone cleavage with various nucleophiles.
References (7)
- et al.
Tetrahedron Lett.
(1989)et al.Synthesis
(1990) - et al.
Synthesis
(1991) - et al.
J. Chem. Soc., Chem. Commun.
(1992)
There are more references available in the full text version of this article.
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1,2,3-Triazole-based analogue of benznidazole displays remarkable activity against Trypanosoma cruzi
2015, Bioorganic and Medicinal ChemistryCitation Excerpt :HRMS (ES+): m/z [M+H]+ calcd for C9H11N4O: 191.0933; found: 191.0941. Characterization data is in accordance with that previously reported.32 To a solution of N-benzyl-2-azidoacetamide (1) (100 mg, 0.52 mmol, 1.0 equiv) and commercial terminal alkyne (1.1 equiv) in DMF (0.3 mL) were added sodium ascorbate (1.0 equiv) and CuSO4 (1 mol L−1 aqueous solution) (0.03 equiv).
Chapter 5.4 Five-Membered Ring Systems: With More than One N Atom
1995, Progress in Heterocyclic Chemistry
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