The chemistry of cadinenes and cadinols
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Medicine in motion: Opportunities, challenges and data analytics-based solutions for traditional medicine integration into western medical practice
2021, Journal of EthnopharmacologyCitation Excerpt :In one of the pairwise comparisons, 121 compounds were shared between the 2 (one Kampo and one TCM) formulations. These were then re-categorised (Fig. 2) using literature analysis into opioid/alkaloid candidate analgesics (alkaloids related to known opioid receptor ligands or ion channel ligands, 4 convergent compounds) (Bienz et al., 2002; Kai et al., 1998; National Center for Biotechnology Information; Nichols and Lee, 2018; Qi et al., 2019; Saeed et al., 1997; Song et al., 2000; Xu et al., 2005; Zhong et al., 1995), potential ligands for nociceptive ion channels (terpenes, 49 convergent compounds), components with other demonstrated neuroactivity (15 convergent compounds), components with bioactivity indirectly related to pain (anti-inflammatory, anti-oxidants, 16 convergent compounds) and compounds with other types of bioactivity but no obvious link to analgesia (56 convergent compounds) (Antwi et al., 2018; Bommareddy et al., 2019; Crupi and Cuzzocrea, 2017; Devi et al., 2015; Do et al., 2019; Henry and Maisch, 1890; Herout and Sykora, 1958; Huang et al., 2015; Hui et al., 2015; Kimura et al., 2001; Ko et al., 2017; Kumar and Muller, 2000; Kwon et al., 2018; Le et al., 2018; Li et al., 2009; Madeo et al., 2018; National Center for Biotechnology Information; Ng et al., 2008; Qian, 2002; Shim et al., 2018; Wang et al., 2019; Ye et al., 2018; Zeisel, 1981). These data are summarized in Fig. 1.
Sesquiterpenes from leaves of Cryptomeria japonica
1995, PhytochemistryNaturally occurring cadinenes
1989, PhytochemistryThe total stereostructure of (-)-muurolene dihydrochloride
1983, Tetrahedron Letters