A seco-phthalideisoquinoline alkaloid from Fumaria indica seeds

doi:10.1016/0031-9422(88)80485-0

Phytochemistry

Volume 27, Issue 6, 1988, Pages 1918-1919

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Abstract

From the seeds of Fumaria indica, a previously undescribed seco-phthalideisoquinoline alkaloid, narceirnicine, has been isolated and its struct

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Cited by (11)

Diverse alkaloids and biological activities of Fumaria (Papaveraceae): An ethnomedicinal group
2020, Fitoterapia
Fumaria species, commonly known as fumitory or earth smoke, are considered weeds in many regions. However, several Fumaria species have long been used in folk medicine, such as F. capreolata L., F. densiflora DC., F. indica (Hausskn.) Pugsley, F. officinalis L., F. parviflora Lam., and F. vaillantii Loisel. as well. The ethnobotany, phytochemistry, and pharmacology of 24 Fumaria species have been investigated. Phytochemical studies on Fumaria species revealed the presence of numerous alkaloids, flavonoids, saponins, and terpenoids. Phthalideisoquinolines (PTIs), protoberberines, and spirobenzylisoquinolines (SBIs) are the major alkaloids in the genus Fumaria. The plants biosynthesize a diverse group of biologically active isoquinoline alkaloids, and these may help to explain the use of various Fumaria species in folk medicine. Pharmacological studies revealed a broad spectrum of bioactivities such as hepatoprotective, anti-inflammatory, antimicrobial, antioxidant, and antitumor activities. We found 159 articles published from 1969–2019 by searching the keyword “Fumaria” using databases such as SciFinder, Google Scholar, and PubMed. Based on our reading of these papers, Fumaria species appear to be a source of bioactive isoquinoline alkaloids and ethnomedicines. The lack of studies on pharmacological mechanisms, pharmacokinetics, clinical efficacy, quality control, and toxicology are discussed in this review. There is great potential for broader medicinal applications of this genus.
Protopine
2020, Naturally Occurring Chemicals against Alzheimer’s Disease
Neurodegenerative diseases such as Alzheimer’s disease (AD) are a debilitating issue and a social burden. Proactive constituents from herbal ingredients isolated from plants have a crucial role in enhancing memory and neuroprotection in dementia-related disorders. An alkaloid-protopine isolated mostly from the Papaveraceae family exhibited several inhibitory activities against cholinesterase enzyme, which stabilizes the cognitive function of the brain. Several methods for synthesizing protopine are reported the easiest of which is the singlet oxygen oxygenation and ring enlargement of indeno[2,1-a][3]benzazepines. Crystal and x-ray studies reveal that strong electrostatic interaction between nitrogen atoms in the 10-membered rings stabilizes the protopine structure. Herbs containing protopine are used in folklore medicine in many countries and possess acetylcholinesterase inhibitory (anti-AD), hepatoprotective, and anticancer activity.
A review on ethnobotany, phytochemistry and pharmacology of Fumaria indica (Fumitory)
2012, Asian Pacific Journal of Tropical Biomedicine
Fumaria indica (Hausskn.) Pugsley (Fumariaceae), known as “Fumitory”, is an annual herb found as a common weed all over the plains of India and Pakistan. The whole plant is widely used in traditional and folkloric systems of medicine. In traditional systems of medicine, the plant is reputed for its anthelmintic, diuretic, diaphoretic, laxative, cholagogue, stomachic and sedative activities and is used to purify blood and in liver obstruction in ethnopharmacology. The whole plant is ascribed to possess medicinal virtues in Ayurvedic and Unani systems of medicine and is also used in preparation of important Ayurvedic medicinal preparations and polyherbal liver formulations. The review reveals that phytochemical constituents of wide range have been separated from the plants and it possesses important pharmacological activities like smooth muscle relaxant, spasmogenic and spasmolytic, analgesic, anti-inflammatory, neuropharmacological and antibacterial activities. The separation of hepatoprotective and antifungal constituents from this plant was also reported newly. This review highlights the traditional, ethnobotanical, phytochemical, pharmacological information available on Fumaria indica, which might be helpful for scientists and researchers to find out new chemical entities responsible for its claimed traditional uses.
Alkaloidal constituents of Fumaria indica
1995, Phytochemistry
Stem alkaloids of Fumaria indica
1992, Phytochemistry
Neuroprotection of Multitargeted Phytochemicals against Alzheimer: A Desperate Need from Nature
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Short reportA seco-phthalideisoquinoline alkaloid from Fumaria indica seeds

Abstract

Phytochemistry

Tetrahedron

Curr. Sci.

Arzneimittel Forsch.

Short report
A seco-phthalideisoquinoline alkaloid from Fumaria indica seeds