Short reportStudies on a bitter principle from Vernonia anthelmintica
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Cited by (34)
Vernonia anthelmintica (L.) Willd.: An ethnomedicinal, phytochemical, pharmacological and toxicological review
2020, Journal of EthnopharmacologyVernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells
2019, Bioorganic ChemistryCitation Excerpt :Data are expressed as mean ± SD from three independent experiments. A bioassay-guided separation of the CH2Cl2 fractions, using a combination of chromatographic methods and HPLC purification, afforded the new elemanolide sesquiterpenoid lactone dimer, named vernodalidimer L (VDi, 1), together with eight known compounds identified by comparison of their spectroscopic data with those reported in the literatures and HRMS analysis, as vernodalin (VDa, 2) [26], vernodalol (VDol, 3) [27], 8-desacylvernodalol (8Des, 4) [28], vernolepin (VLe, 5) [29], vernolide (VLi, 6) [30], vernomygdin (Vmy, 7) [26,31], 11,13-dihydrovernolide (11,13DLi, 8) [32,33], and 19-hydroxyvernolide (19HLi, 9) [32] (Fig. 1). We have provided the complete and unambiguous 1H- and 13C NMR assignment of all isolated compounds (see Supplementary data), especially for the vernomygdin (7) which was first reported by Kupchan [26].
Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities
2017, Phytochemistry LettersCitation Excerpt :H-6 and H-6′ are arbitrarily assigned in the α-orientation as in the literature (Liu et al., 2010; Turak et al., 2015). The coupling constants 3JH-6/H–7 = 10.7 Hz and the NOESY correlations of H-6/H-8, H-7/H-5, and H-5/H-1 indicated that the relative configuration of moiety A is the same with vernodalol (Asaka et al., 1977; Liu et al., 2010). For the moiety B, the NOESY correlations of H-6′/H-8′ indicated that they had α-orientation.
Elemanolide dimers from seeds of Vernonia anthelmintica
2015, FitoterapiaCitation Excerpt :Plants of V. anthelmintica only grow in high-altitude areas of southern Xinjiang, small regions of Pakistan and a little part of India. Previous phytochemical studies yield two novel orthoester elemanolide dimers [6], two guaianolides [7], and four elemanolides [8,9]. Elemanolide dimers showed significant cytotoxicity against human cell lines [6].
Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina
2006, Journal of Ethnopharmacology