Carcinoma of the oral cavity evaluated by specific red cell adherence test

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Abstract

The specific red cell adherence (SRCA) test which demonstrates in tissue the presence (positive) or absence (negative) of normal isoantigens A, B, and H was applied to sections from thirty-two cases of oral cavity carcinoma. The sources of these carcinomas included the tongue, floor of the mouth, gingiva, palate, alveolar ridge, lip, buccal mucosa, and maxillary ridge, and the microscopic types included carcinoma in situ, early invasive squamous carcinoma, and infiltrating squamous carcinoma of good, moderate, and poor differentiation. Complete or almost complete loss of isoantigens was demonstrated in invasive squamous carcinoma and partial loss of isoantigens in in situ cases, compared with forty-nine examples of normal oral mucosa, none of which showed loss of isoantigens. In well-differentiated squamous carcinoma the isoantigens were lost by the malignant cells but were often retained by the keratin. Built-in positive controls (normal squamous epithelium and blood vessel endothelium) often showed negative SRCA if the area had been previously irradiated.

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