Temporal sequence of changes in central noradrenergic system of rat after prolonged antidepressant treatment: Receptor desensitization and neurotransmitter interactions
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Monoaminergic and aminoacidergic receptors are involved in the antidepressant-like effect of ginsenoside Rb1 in mouse hippocampus (CA3) and prefrontal cortex
2018, Brain ResearchCitation Excerpt :These results are similar to those of previous reports (Bruning et al., 2011), implying that the serotonergic receptors may be involved in the antidepressant action of Rb1. The role of the noradrenergic receptor has also been studied in the pathophysiology of depressive disorders (Racagni et al., 1983). Although the α and β subtypes of the adrenergic receptors are the basic targets of the endogenous neurotransmitters noradrenaline (NA) and adrenaline, α-adrenoceptors are widely distributed in the central nervous system.
Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics
2006, Brain ResearchCitation Excerpt :Down-regulation of the MAT is one such molecular change. Chronic treatment with desipramine has been reported to decrease the density of binding sites for nisoxetine, a high affinity ligand for NET (Bauer and Tejani-Butt, 1992; Weinshenker et al., 2002; Benmansour et al., 2004) or norepinephrine uptake (Benmansour et al., 2004), although some studies report an increase or no change in NET density with chronic desipramine treatment (Biegon 1986; Shores et al., 1994; Racagni et al., 1983; Cheetham et al., 1996). These differences may arise from differences in various experimental conditions including dosage, duration of treatment of and withdrawal from desipramine.
Regulation of the norepinephrine transporter by chronic administration of antidepressants
2004, Biological PsychiatryChronic myo-inositol increases rat brain phosphatidylethanolamine plasmalogen
2001, Biological PsychiatryCitation Excerpt :Membrane biophysical, signal transduction, and transport studies suggest membrane abnormalities in affective disorders (Hitzemann et al 1986; Jope et al 1996; Peet et al 1998; Pettegrew et al 1982; 1993; Szentistvanyi et al 1980). Antidepressants including tricyclics are reported to induce alterations in membrane phospholipid turnover and composition (Honegger et al 1983), to increase incorporation of methyl groups into membrane lipids (Racagni et al 1983), and to normalize membrane structural dynamics of bipolar patients (Pettegrew et al 1993). This study examines whether acute and chronicmyo-inositol administration induces alterations in rat brain membrane phospholipids that provide molecular insights into the therapeutic action of myo-inositol in affective disorders.
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Present address: Fidia Research Laboratories, Abano Terme, Italy.