Elsevier

Neuropharmacology

Volume 18, Issue 11, November 1979, Pages 917-920
Neuropharmacology

γ-Hydroxybutyrate potentiates the action of dopamine

https://doi.org/10.1016/0028-3908(79)90092-3Get rights and content

Abstract

By using the method of microiontophoresis, the influence of sodium hydroxybutyrate (GHB) and dopamine (DA) on spontaneous, extracellularly recorded, electrical activity of frontal cortical neurones of the rabbit was studied. Both agents produced predominantly inhibitory effects on neuronal activity. The inhibitory effect of DA was potentiated during GHB applications to the neurones in doses which per se failed failed to induce neuronal depression. Sodium hydroxybutyrate prevented the ‘escape’ of neurones from the inhibitory effect of DA and increased the duration of recovery of cellular activity after the application of DA was stopped. It is suggested that γ-hydroxybutyrate prevents the process of DA inactivation.

References (4)

There are more references available in the full text version of this article.

Cited by (0)

View full text