Insulin-mediated glucose uptake by individual tissues during sepsis☆
References (41)
- et al.
Differentiation between septic and postburn insulin resistance
Metabolism
(1989) - et al.
Local effect of burn on skeletal muscle insulin responsiveness
J Surg Res
(1981) - et al.
Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues
Biochem Biophys Res Commun
(1987) - et al.
The positive inotropic action of insulin in the canine heart
Eur J Pharmacol
(1972) - et al.
Contribution of different organs to increased glucose consumption after endotoxin administration
J Biol Chem
(1987) - et al.
Post-traumatic insulin resistance in uninjured forearm tissue
J Surg Res
(1984) - et al.
The role of the skin in carbohydrate metabolism
Adv Metab Dis
(1972) - et al.
Hormonal and metabolic responses to glucose infusion in sepsis studied by the hyperglycemic glucose clamp technique
J Parenter Enteral Nutr
(1987) - et al.
In vivo insulin resistance during nonlethal hypermetabolic sepsis
Circ Shock
(1989) - et al.
Skeletal muscle insulin unresponsiveness during chronic hyperdynamic sepsis in the dog
J Trauma
(1985)
In vivo skeletal muscle insulin resistance during E coli endotoxin shock in dogs
Circ Shock
Skeletal muscle insulin resistance during Escherichia coli bacteremia shock in the dog
Surgery
The effect of insulin on glucose uptake and soleus muscle during hemorrhagic shock
Can J Physiol Pharmacol
Basal and insulin-stimulated skeletal muscle sugar transport in endotoxin and bacteremia rats
Am J Physiol
Heterogeneity of insulin action in muscle: Influence of blood flow
Am J Physiol
Dose-response curves for in vivo insulin sensitivity in individual tissues in rats
Am J Physiol
A (3H)2-deoxyglucose method for comparing rates of glucose metabolism and insulin responses among rat tissues in vivo
Diabetes
Insulin action and binding in adipocytes exposed to endotoxin in vitro and in vivo
Circ Shock
Insulin resistance and depressed gluconeogenic capability during early hyperglycemic sepsis
J Trauma
Myocardial insulin resistance during acute endotoxin shock in dogs
Diabetes
Cited by (93)
Invited review: The influence of immune activation on transition cow health and performance—A critical evaluation of traditional dogmas
2021, Journal of Dairy ScienceCitation Excerpt :Immune activation induces marked alterations in whole-body glucose dynamics as a result of increased leukocyte glucose requirements. Endotoxemia causes whole-body insulin resistance (Lang et al., 1985; Vernay et al., 2012), which specifically reflects a reduction in insulin-mediated glucose uptake by peripheral tissues such as skeletal muscle and adipose (Spitzer et al., 1980; Lang et al., 1990). Some reports indicate increased adipose tissue glucose uptake (Lang et al., 1992); however, this is likely explained by the presence of resident macrophages that utilize glucose (Weisberg et al., 2003).
Biology of heat stress; the nexus between intestinal hyperpermeability and swine reproduction
2020, TheriogenologyCitation Excerpt :After activation by an antigen, most of the immune system initiates a metabolic shift away from oxidative phosphorylation to aerobic glycolysis, and glucose becomes the primary fuel, a mechanism broadly referred to as the Warburg effect [123]. To maximize glucose delivery to the immune system, the intestine increases its glucose absorptive capacity (discussed above), hepatic glucose output increases, and skeletal muscle becomes insulin resistant (i.e., it utilizes less glucose) [124,125]. The blunted adipose tissue mobilization (especially compared to pair-fed controls) is likely a homeorhetic strategy preventing leukocyte substrate competition as fatty acid (and ketone) availability/utilization reduce glucose uptake; a phenomenon known as the Randle effect [126].
Effect of bovine genotype on innate immune response of heifers to repeated lipopolysaccharide (LPS) administration
2019, Veterinary Immunology and ImmunopathologyEffects of continuous and increasing lipopolysaccharide infusion on basal and stimulated metabolism in lactating Holstein cows
2019, Journal of Dairy ScienceCitation Excerpt :During immune activation, a variety of coordinated metabolic adjustments occur, including hyperglycemia or hypoglycemia (depending upon the stage and severity of infection; Waldron et al., 2003; Kvidera et al., 2017), increased circulating insulin and glucagon (Waldron et al., 2003), skeletal muscle catabolism (Wannemacher et al., 1980), and hypertriglyceridemia (Filkins, 1978; Wannemacher et al., 1980; Lanza-Jacoby et al., 1998; McGuinness, 2005). Further, milk synthesis is reduced (Lohuis et al., 1988; Waldron et al., 2003; Gröhn et al., 2004) and skeletal muscle and adipose tissue become insulin insensitive (Lang et al., 1990) during immune activation. Collectively, the aforementioned changes in endocrine signaling and nutrient trafficking are presumably strategies to ensure adequate glucose delivery to activated immune cells.
Effect of chromium on bioenergetics and leukocyte dynamics following immunoactivation in lactating Holstein cows
2018, Journal of Dairy ScienceCitation Excerpt :During an immune challenge circulating insulin increases, likely because insulin facilitates immune cell glucose uptake and improves function (Walrand et al., 2004). In an attempt to spare glucose for the immune system, muscle and adipose tissue become insulin resistant (Lang et al., 1990) and milk synthesis is reduced (Kvidera et al., 2017b). However, the ubiquitous nature of leukocytes makes quantifying the immune system's in vivo glucose consumption difficult.
A 100-Year Review: Regulation of nutrient partitioning to support lactation
2017, Journal of Dairy Science
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Supported by National Institutes of Health Grant No. GM 38032 (C.H.L.)
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Dr Meszaros' present address is Naval Medical Research Institute, Surgical Research Division, Bethesda, MD 20814.