Elsevier

Life Sciences

Volume 59, Issue 12, 16 August 1996, Pages PL185-PL190
Life Sciences

Pharmacology letter Accelerated communication
Role of interleukin-1β, interleukin-6 and macrophage inflammatory protein-1β in prostaglandin-E2-induced hyperthermia in rats

https://doi.org/10.1016/0024-3205(96)00410-9Get rights and content

Abstract

The purpose of this study was to investigate the role of pyrogenic cytokines, such as IL-1β, IL-6 and MIP-1β, in the mechanisms underlying the hyperthermic response of rats to central injection of PGE2. Thus, specific murine neutralizing antibodies against these cytokines were microinjected directly into the anterior hypothalamic, preoptic area (AH/POA) of unrestrained rats just before intracerebroventricular injection of PGE2. The significant hyperthermia induced by PGE2 was markedly suppressed by micro-injection of anti-IL-6 and partially attenuated by anti-IL-1β. However, the micro-injection of anti-MIP-1β failed to alter the hyperthermic response. The results indicate that PGE2-induced hyperthermia is presumably mediated through actions of IL-6 on the thermosensitive cells of the AH/POA and confirm that distinct and alternate pathways exist in the rat brain for the induction of fever.

References (21)

  • S.V. Vellucci et al.

    Brain Res.

    (1994)
  • C.W. Simpson et al.

    Neurosci. Biobehav. Rev.

    (1994)
  • F.J. Miñano et al.

    Pharmacol. Biochem. Behav.

    (1991)
  • F.J. Minano et al.

    Brain Res. Bull.

    (1990)
  • R.P. Phipps et al.

    Immunology Today

    (1991)
  • W.D. Ruwe et al.

    Brain Res. Bull.

    (1980)
  • M.J. Kluger

    Physiol. Rev.

    (1991)
  • T. Oka et al.

    Am. J. Physiol.

    (1994)
  • J.T. Stitt
  • C.M. Blatteis
There are more references available in the full text version of this article.

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