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Preparation and enantioselectivity of (S)-binaphthol-bonded phase for high-performance liquid chromatography

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Abstract

A novel chiral stationary phase (CSP) for high-performance liquid chromatography was prepared by covalently bonding (S)-2,2′-dihydroxy-1,1′-binaphthyl to silica gels. This CSP showed enantioselectivity mainly for secondary and tertiary amines. The experimental results suggested that the free hydroxyl groups of the binaphthol moiety play a very important phase in the retention and the chiral recognition on this CSP. Addition of trifluoroacetic acid or diethylamine to a mobile phase affected the peak shape and the enantioselectivity. Trifluoroacetic acid improved the resolution between enantiomers for many analytes.

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