Glomerular function
Recent observations on the proximal tubular transport of acidic and basic amino acids by rat renal proximal tubular brush border vesicles

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Abstract

  • 1.

    1. Transport of l-glutamic acid by rat renal brush border membrane vesicles is sodium-dependent.

  • 2.

    2. Present at the inner membrane surface potassium stimulates sodium-dependent L-glutamic acid uptake.

  • 3.

    3. Sodium stimulated l-glutamic acid uptake is potential-sensitive only in the presence of potassium.

  • 4.

    4. Transport of l-ornithine can also be stimulated by a sodium gradient.

  • 5.

    5. However, in the absence of sodium, l-ornithine seems to cross the membrane by facilitated diffusion.

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