Hepatocellular carcinoma without cirrhosis in Japanese patients
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Porto-sinusoidal vascular disorder
2022, Journal of HepatologyPlatelet-related phenotypic patterns in hepatocellular carcinoma patients
2014, Seminars in OncologyCitation Excerpt :Thrombocytopenia is a cirrhosis surrogate, an HCC risk factor, and a prognostic factor, and is associated with small HCCs.7–13,16,17 Non-cirrhotic HCCs can be large,22–24 and are associated with thrombocytosis,25 which is a general sign of early malignancy.26 We found that small tumors (38.8% of the total cohort) were significantly associated with higher blood albumin and lower bilirubin, AST, and GGTP levels, all consistent with better liver function, despite the liver fibrosis that thrombocytopenia likely reflects (Table 1).
Latin American Association for the Study of the Liver (LAASL) Clinical Practice Guidelines: Management of Hepatocellular Carcinoma
2014, Annals of HepatologyCitation Excerpt :Psychosocial and spiritual support of the patient must be provided by a multidisciplinary team of physicians, nurses, pharmacists, social workers, and religious advisors to help patients and families.253 In the general population, 15-20% of HCCs occur in the noncirrhotic liver,254 but these figures vary from 7% to 54% between geographic areas and according to the liver disease etiology.255 –260 Noncirrhotic HCC affects patients with no evidence of liver disease or with inflammatory, fibrotic, or degenerative liver diseases (e.g., chronic viral hepatitis, HH, and NASH).
Association of abnormal plasma bilirubin with aggressive hepatocellular carcinoma phenotype
2014, Seminars in OncologyCitation Excerpt :The principal finding in this study was an association of abnormal plasma bilirubin with elevated levels of three indices of clinical HCC aggressive biology, namely, plasma AFP levels, PVT, and tumor multifocality. Large tumors have previously been noted to occur in patients with preserved liver function13–15 and this has been thought to be due in part to the likelihood of liver decompensation and death that result when HCCs grow in severely damaged livers. However, we tried to account for this by examining different tumor size terciles (Table 2) and found the association of abnormal bilirubin with aggressive HCC features even in patients with small size tumors, which could not be causing liver failure.
Should Treatment of Hepatitis B Patients Be Based Solely on Liver Fibrosis?
2013, Clinical Gastroenterology and Hepatology