Gastroenterology

Gastroenterology

Volume 87, Issue 3, September 1984, Pages 660-663
Gastroenterology

Hepatocellular carcinoma in primary biliary cirrhosis: Detection by α-fetoprotein estimation

https://doi.org/10.1016/0016-5085(84)90540-7Get rights and content

Abstract

Serial estimations of serum α-fetoprotein in 130 white patients from the United Kingdom with primary biliary cirrhosis who were followed for periods of 1–52 mo revealed 5 cases of hepatocellular carcinoma; all were subsequently confirmed histologically. At the time α-fetoprotein was first noted to be elevated, none had signs or symptoms of tumor development. Of the 52 patients who died during the follow-up period, hepatocellular carcinoma was the cause of death in 3 (33%) of the 9 men, and 2 (5%) of the 43 women. Allowing for the marked predominance of women among patients with primary biliary cirrhosis, hepatocellular carcinoma may be no less frequent in primary biliary cirrhosis than in other types of cirrhosis.

References (13)

  • S Sherlock

    Primary biliary cirrhosis (chronic intrahepatic obstructive jaundice)

    Gastroenterology

    (1959)
  • DT Purtilo et al.

    Cirrhosis and hepatoina occurring at Boston City Hospital (1917–1968)

    Cancer

    (1973)
  • WD Stone et al.

    The natural history of cirrhosis

    Q J Med

    (1968)
  • HA Edmondson et al.

    Neoplasms of the liver

  • N Krasner et al.

    Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases

    Gut

    (1979)
  • J Roll et al.

    The prognostic importance of clinical and histological features in asymptomatic and symptomatic primary biliary cirrhosis

    N Engl J Med

    (1983)
There are more references available in the full text version of this article.

Cited by (80)

  • Hepatocellular carcinoma

    2018, Practical Hepatic Pathology: A Diagnostic Approach: Second Edition
  • Hepatocellular Carcinoma

    2011, Practical Hepatic Pathology: A Diagnostic Approach A Volume in the Pattern Recognition Series, Expert Consult: Online and Print
  • Natural history of primary biliary cirrhosis

    2008, Gastroenterologia y Hepatologia
  • Tumors of the Liver—Pathologic Aspects

    2006, Surgery of the Liver, Biliary Tract and Pancreas: Volumes 1-2, Fourth Edition
View all citing articles on Scopus
View full text