Enhanced superoxide radical production by stimulated polymorphonuclear leukocytes in a cat model of diabetes
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The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases
2020, Experimental Eye ResearchCitation Excerpt :The proposed mechanism behind these changes relate in part to the greater numbers of polymorphonuclear neutrophils in diabetics compared to healthy individuals (Lutty et al., 1997). Indeed, neutrophils from diabetic patients have a greater oxidative burst (Freedman and Hatchell, 1992) and a more rigid cytoplasmic membrane which leads to vaso-occlusive events (Kelly et al., 1993). Raised levels of ROS are associated with retinal neuronal degeneration (Sasaki et al., 2010).
Diabetic choroidopathy
2017, Vision ResearchCitation Excerpt :Our focus was on PMNs because, once firmly adherent, they can undergo an oxidative burst that can damage endothelial cells (Springer, 1994). PMNs from diabetics exhibit a great oxidative burst than nondiabetic PMNs (Baranao, Garberi, Tesone, & Rumi, 1987; Freedman & Hatchell, 1992). Diabetic PMNs have a more rigid cytoplasmic membrane than nondiabetic PMNs making them more likely to be trapped in the microvasculature and cause capillary occlusion (Kelly, Barden, Tiedeman, & Hatchell, 1993).
Cellular connections, microenvironment and brain angiogenesis in diabetes: Lost communication signals in the post-stroke period
2015, Brain ResearchCitation Excerpt :These effects were mediated through CD11/CD18–ICAM-1 interactions (adhesion) and P-selectin (rolling). Other studies showed decreased membrane fluidity (Masuda et al., 1990), and enhanced superoxide production (Freedman and Hatchell, 1992) by granulocytes isolated from diabetic animals. Clinically, neutrophils isolated from diabetic patients produced significantly greater amounts of superoxide anions, which correlated negatively with patients’ glycemic control (Karima et al., 2005; Wierusz-Wysocka et al., 1987).
NADPH-dependent reductases and polyol formation in human leukemia cell lines
2003, Chemico-Biological InteractionsCitation Excerpt :Various bacterial infections occur with higher incidence in diabetic patients. Diabetics also develop leukocyte dysfunctions which include chemotaxis [1–3], phagocytosis [3], killing [3–5] and oxidative metabolism [6,7]. Furthermore, in the development of microangiopathies associated with diabetes, leukocytes appear to play an important role.
Feline Heinz bodies interfering in standard bicarbonate analysis by the ABL90 FLEX
2023, Veterinary Clinical Pathology
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Current address: Department of Ophthalmology, U.N.C.-Chapel Hill, Chapel Hill, NC 27514, U.S.A.