The angiogenic activity of the fibroblast and epidermal growth factor
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2022, Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy: volume 18Comparative analysis of secretory factors from permanent- and deciduous-teeth periodontal ligament cells
2016, Archives of Oral BiologyCitation Excerpt :EGF and IGF-1, which are well-known proangiogenic factors, were also expressed more strongly in P-PDL-CM than in D-PDL-CM. It was reported that EGF treatment increased angiogenesis in an in vivo rabbit cornea model (Gospodarowicz, Bialecki, & Thakral, 1979), and that IGF-1 increased the migration of human endothelial cells and in vitro tubular formation (Shigematsu et al., 1999). Angiogenesis is crucial for tissue engineering, and so P-PDL cells might be a more useful source than D-PDL cells for tissue regeneration.
Basic fibroblast growth factor-encapsulated PCL nano/microfibrous composite scaffolds for bone regeneration
2015, PolymerCitation Excerpt :The fibroblast growth factor (FGF) family is the representative growth factor which has shown the potential effects on the repair and regeneration of tissues [7–12]. Basic fibroblast growth factor (bFGF), one member of this family, induces the production of proteases in endothelial cells and is a strong angiogenic factor in vitro, and it stimulates neovascularization in vivo [13–15]. In spite of these essential advantages in tissue engineering, it has a restricted application due to its short biological half-life in circulation (usually several minutes) and rapid degradation in vivo [2–4].
Angiogenic factors in bone local environment
2013, Cytokine and Growth Factor ReviewsCitation Excerpt :Like VEGF, BMP7 gene and protein expression is upregulated in osteocytes in response to mechanical loading by pulsatile fluid shear stress [69]. EGF has been shown to directly stimulate epidermal growth and keratinization [173,174], and play an important role in angiogenesis [175]. EGF is a single polypeptide chain consisting of 53 amino acid residues.
Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone
2008, Principles of Bone Biology: Volume 1-2, Third Edition