Tissue distribution of keratin 7 as monitored by a monoclonal antibody☆
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2019, Tissue and CellCitation Excerpt :Their findings were also based on light and ultrastructural morphology rather than confirmation by immunohistochemical methods (Schier and Schier, 1987). Based on strong immunoreactivity to pancytokeratin and CK-7, a marker of mature biliary epithelial cells (Joplin, 1994; Ramaekers et al., 1987) we can conclude that the cultured cells were of epithelial nature originating from intact bile duct epithelium. So far, there is only single study by Ochiai K et al, which showed successful culture of BECs from atretic bile duct in BA patients (Ochiai et al., 2004).
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2015, Experimental Eye ResearchImmunohistochemical expression of cytokeratins in human salivary gland acinic cell carcinomas
2015, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :In the present study, we evaluated the IHC staining profile of a series of CKs in different subtypes of AcCC and in normal salivary glands in order to identify patterns of expression that could facilitate the diagnosis of each subtype of AcCC and its origin. CK7, a 54-kDa polypeptide, has been demonstrated in various types of simple epithelia, including those of the lung, cervix, breast, bile ducts, collecting ducts of the kidney, and bladder.33-36 However, its expression is absent from the gastrointestinal epithelium, hepatocytes, proximal and distal tubules of the kidney, and squamous epithelium.37
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This study was supported by the Netherlands Cancer Foundation.