Regular paperEbelactone B, an inhibitor of urinary carboxypeptidase Y-like kininase, prevents the development of deoxycorticosterone acetate-salt hypertension in rats
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Cited by (19)
A synthesis of (-)-ebelactones A and B
2010, TetrahedronCitation Excerpt :The ebelactones display a wide range of biological activity consequent to the irreversible acylation of various serine hydrolases by the strained β-lactone moiety.3,4 Examples together with their protein targets include suppressed fat absorption (intestinal lipase),5 suppression of platelet aggregation (cathepsin A/deamidase),6 antihypertension (urinary kininase)7,8 and immunostimulation (N-formylmethionine aminopeptidase).1 In addition, the ebelactones inhibit cutinases produced by fungal plant pathogens thereby blocking the initial step of plant infection,9,10 and they reduce the destruction of human epidermal and epithelial tissue by pathogenic yeast.11
Pharmacology and cardiovascular implications of the kinin-kallikrein system
1999, Japanese Journal of PharmacologyRole of the renal kallikrein-kinin system in the development of hypertension
1997, Immunopharmacology
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