Elsevier

Brain Research

Volume 461, Issue 2, 4 October 1988, Pages 393-396
Brain Research

Transient increased density of NMDA binding sites in the developing rat hippocampus

https://doi.org/10.1016/0006-8993(88)90275-2Get rights and content

Abstract

Using quantitative autoradiography and membrane preparations, the density of specific glutamate andN-methyl-d-aspartic acid (NMDA) binding sites have been determined in the developing rat hippocampus. We found an abrupt reduction in the density of NMDA binding sites after P8 (postnatal day) without change in affinity. The transient expression of NMDA receptors during maturation suggests that they may play a particularly important role in synaptogenesis.

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    **

    We are endebted to G. Charton for his help in experiments and to S. Guidasci for illustrations.

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