Transient increased density of NMDA binding sites in the developing rat hippocampus
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Cited by (261)
Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring
2021, Epilepsy and BehaviorCitation Excerpt :This difference is because downregulation of KCC2 and upregulation of NKCC1 are observed in the immature brain and thus Cl− concentration inside the cell becomes higher than the concentration outside the cell [21,22]. In addition, Tremblay E et al. showed that the density of [3H]-labeled glutamate-binding NMDA receptors in the hippocampus of Wistar rats reached a maximum at the age of 8 days and decreased thereafter and became similar to that of adults at the age of 13 days [23]. Accordingly, it is considered that changes in intracellular/extracellular ion balance and changes in receptor expression level with age might be related to age-related fever resistance and febrile seizure sensitivity.
Drug delivery platforms for neonatal brain injury
2021, Journal of Controlled ReleaseCitation Excerpt :The increased excitability of the developing brain facilitates neural circuit formation, but also renders a greater risk of severe excitotoxicity in neonates than adults [44]. For example, postnatal day (P) 6-8 rats express NMDA-sensitive glutamate binding sites in the stratum radiatum of the hippocampal CA1 region at approximately twice of adult levels [103], and the subunit composition of immature NMDAR allows for a boosted calcium influx [46]. Thus, the quantity and type of NMDAR expressed may account for the increased cell death in P7 than adult rats upon intra-striatal N-methyl-D-aspartate injection [104].
Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity
2020, Cell ReportsCitation Excerpt :In CA1 pyramidal cells, the loss of dendritic arborization centered on the hippocampal stratum radiatum, a site of synaptic targets of axons from area CA3 and a pattern identified before (Brunson et al., 2005; Ivy et al., 2010; Patterson et al., 2017). These CA1 neurons, their dendrites, and their synapses actively develop during the first post-natal week in the rat (Tremblay et al., 1988; Tyzio et al., 1999), following the slightly earlier development of CA3 pyramidal cells. Both CA1 and CA3 neurons were affected by ELA, and it is likely that the arborization of these neurons requires the expression of NRSF target genes, because blocking NRSF function following ELA prevented dendritic impoverishment of these neurons.
Pathophysiology
2018, Volpe's Neurology of the NewbornNeonatal Seizures
2018, Volpe's Neurology of the Newborn
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We are endebted to G. Charton for his help in experiments and to S. Guidasci for illustrations.