Elsevier

Brain Research

Volume 148, Issue 1, 9 June 1978, Pages 245-250
Brain Research

Dopamine and norepinephrine enhancement in discrete rat brain regions following neonatal 6-hydroxydopamine treatment

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    In trained control animals compared to untrained controls concentrations of the DA metabolites 3,4‐dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3‐methoxytyramine (3MT) were unchanged. Since 6‐OHDA‐induced depletions have generally been regarded up to now as being irreversible (e.g., Oke, Keller, & Adams,1978), these findings were surprising to say the least. We, therefore, performed a replication of this study in another group of neonatal vehicle (control) and 6‐OHDA‐treated animals but added a group of age‐matched, food‐deprived but untrained neonatal 6‐OHDA‐treated rats as additional control groups (Stodgell, Schroeder, & Tessel, 1996).

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The support of this work by the National Institutes of Health via grant RO1 NS08740 is gratefully acknowledged.

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