Dopamine and norepinephrine enhancement in discrete rat brain regions following neonatal 6-hydroxydopamine treatment
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Cited by (52)
Dynamic changes in dopamine neuron function after DNSP-11 treatment: Effects in vivo and increased ERK 1/2 phosphorylation in vitro
2014, PeptidesCitation Excerpt :An appreciable decline (data not quantified) in amplitude was evident in more ventral recording depths (Fig. 4) compared to dorsal subregions. This decline was consistent with previous studies using the same methodology and reflects a corresponding decrease in DA nerve terminal density ventrally [20,43]. Of greater interest than the depth variable was the treatment effect of DNSP-11.
Chapter 6 Animal Models of Self-Injurious Behavior. Induction, Prevention, and Recovery
2008, International Review of Research in Mental RetardationCitation Excerpt :In trained control animals compared to untrained controls concentrations of the DA metabolites 3,4‐dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3‐methoxytyramine (3MT) were unchanged. Since 6‐OHDA‐induced depletions have generally been regarded up to now as being irreversible (e.g., Oke, Keller, & Adams,1978), these findings were surprising to say the least. We, therefore, performed a replication of this study in another group of neonatal vehicle (control) and 6‐OHDA‐treated animals but added a group of age‐matched, food‐deprived but untrained neonatal 6‐OHDA‐treated rats as additional control groups (Stodgell, Schroeder, & Tessel, 1996).
The support of this work by the National Institutes of Health via grant RO1 NS08740 is gratefully acknowledged.