Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation☆
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Neurobiological basis of motivational deficits in psychopathology
2015, European NeuropsychopharmacologyCitation Excerpt :The effects of tetrabenazine on effort-related decision making were reversed by the adenosine A2A antagonist MSX-3 and the antidepressant bupropion, which blocks catecholamine uptake. These results demonstrate that tetrabenazine, which is used in animal models to produce depression-like effects (Preskorn et al., 1984; Kent et al., 1986; Wang et al.. 2010), can alter effort-related choice behavior. Taken together, these preclinical results are consistent with human studies of effort-related decision making showing that decreased selection of high effort/high reward options is seen in patients with major depression (Treadway et al., 2012b).
Brattleboro rats exhibit normal Pa<inf>co<inf>2</inf></inf>-induced changes in cerebral microcirculation
1989, Biological PsychiatryCaffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression
2018, Frontiers in PharmacologyMesolimbic dopamine and the regulation of motivated behavior
2016, Current Topics in Behavioral Neurosciences
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Supported in part by a Clinical Pharmacology Fellowship from the Pharmaceutical Manufacturers Association Foundation (T.A.K.) and by NINDCS Grant NS-17252 and NIMH Research Scientist Development Award MH-00272 (S.H.P.).