Elsevier

Biochemical Pharmacology

Volume 33, Issue 11, 1 June 1984, Pages 1725-1728
Biochemical Pharmacology

Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex

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Abstract

In the presence of ferric ions, doxorubicin forms a complex which self-reduces the iron moiety to form a ferrous complex. This ferrous complex can generate active radicals able to degrade deoxyribose as well as form a species greatly stimulatory towards lipid peroxidation. Both reactions may explain the damage to different sites within the body associated with doxorubicin therapy.

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