Vitamin E inhibits protein kinase c activity

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Abstract

Vitamin E (dl-α-tocopherol) has been found to inhibit in vitro brain protein kinase c with a half inhibitory concentration of 450 μM. The known plasma concentrations of vitamin E are one order of magnitude lower than the protein kinase c half-inhibitory concentration but it is also known that, at the membrane level where the active protein kinase c is located, the lipophilic vitamin E is more concentrated (Burton, G.W., Joyce, A. and Ingold, K.U. and Locke, S. (1983) Arch. Biochem. Biophys. 221, 281–290). It appears that vitamin E, in addition to its antioxidant function, may play a role in regulating the activity of protein kinase c.

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    Citation Excerpt :

    For instance, we can mention the protein translational regulation in the ribosome (Dever, 2002) or enzymatic activity of lipogenesis and desaturase (Chung et al., 2007). Turning back to the cell-signaling function of vitamin E, the first non-antioxidant effect of this vitamin was reported by Mahoney and Azzi (1988), who demonstrated that it can inhibit protein kinase C activity. Rimbach et al. (2002) and Barella et al. (2004) also demonstrated that vitamin E had effects on gene expression in the liver of rats and the liver carcinoma cells.

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