Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Incorporation of Δ6- and Δ5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n − 6 or n − 3 fatty acids
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Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats
2009, Journal of Lipid ResearchCitation Excerpt :Unlike circulating triacylglycerol and phospholipid, cholesteryl ester was minimally labeled (Table 3) during [U-13C]EPA infusion. Together, the observations confirm that the liver channels plasma-derived unesterified n-3 PUFAs and their elongation products into different stable lipids (68), which are assembled in VLDLs and secreted into blood (36–39). In summary, whole-body (presumably liver) synthesis secretion rates of esterified DPA and DHA from circulating unesterified EPA were quantified by infusing [U-13C]EPA intravenously for 2 h in unanesthetized rats fed an n-3 PUFA-containing diet.
One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats
2006, Journal of Lipid ResearchCitation Excerpt :This was surprising, because n-3 PUFAs can bind to peroxisome proliferator-activated receptor transcription factors that activate gene expression of enzymes involved in fat oxidation (84). The Zucker diabetic rat has a decreased weight gain when fed fish oil containing DHA and eicosapentaenoic acid (EPA, 20:5n-3) (85), and transgenic mouse models of obesity, when fed excess α-LNA, show reduced weight gain and body fat content, and upregulated oxidative enzymes in the intestine and adipose tissue (86, 87). One possibility is that the high caloric or saturated fat content of our diets (11) negated an effect of n-3 PUFA deprivation on weight reduction.
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