Effect of allopurinol on the accumulation of xanthine dehydrogenase in liver and pancreas of chicks after hatching
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Cited by (19)
The effect of allopurinol administration on mitochondrial respiration and gene expression of xanthine oxidoreductase, inducible nitric oxide synthase, and inflammatory cytokines in selected tissues of broiler chickens
2015, Poultry ScienceCitation Excerpt :XOR gene expression was increased (P = 0.051) in the liver tissue of ALLO 2 birds as compared to the CON 2 group (Figure 7B). In agreement with previous studies (Lee and Fisher, 1972; Settle et al., 2012), there was no adverse effect after 1 wk AL treatment on BW as compared to control. These results also confirm a study in which chicks were administered AL (750 mg/kg feed) from hatch to 28 d and noted no adverse effects on BW (Lee and Fisher, 1972).
The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers
2012, Poultry ScienceCitation Excerpt :Allopurinol reduced BM gain of the birds, and after 3 wk of treatment, BM in AL, UAF, and UAI birds was only 67, 69, and 68% of that in controls, respectively. However, our results contrast with data from another study done by Lee and Fisher (1972), who fed chicks allopurinol (750 mg/kg of feed) from hatch to 28 d and noted no adverse effects of allopurinol on BM of the birds. Interestingly, there was a rebound in BM in the AR group compared with birds retained on allopurinol.
Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens
2010, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyDetermination of xanthine oxidoreductase activity in broilers: Effect of pH and temperature of the assay and distribution in tissues
2009, Poultry ScienceCitation Excerpt :These results may be related to the role of uric acid as the end product of the metabolism of nitrogen-containing compounds in birds. Other studies have shown changes in enzyme activity in response to the administration of antibiotics (Hartsook et al., 1959), enzyme inhibitors (Lee and Fisher, 1972), or different levels of protein (Pons et al., 1986; Nagahara et al., 1987). These results indicate that the relative activity of the enzyme in different tissues can be affected by different factors, which may partly explain the discrepancies observed in the various studies that investigated the tissue distribution pattern of the enzyme.
Ontogeny and control of xanthine dehydrogenase in Locusta migratoria L.
1979, Insect BiochemistryCoordinate regulation of purine nucleoside phosphorylase and xanthine dehydrogenase levels in chick liver
1973, Archives of Biochemistry and Biophysics