HLA Typing in Birdshot Chorioretinopathy
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Rational laboratory testing in uveitis: A Bayesian analysis
2021, Survey of OphthalmologyAssociation study of MICA-TM and HLA-class I polymorphism with uveitis in South Tunisian population
2015, Pathologie BiologieMolecular Genetic Advances in Uveitis
2015, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Birdshot chorioretinopathy (BCR) is a noninfectious uveitis entity that is confined to the eye. It is a chronic, bilateral, and posterior uveitis with a distinctive clinical presentation and has an almost 100% genetic association with HLA-A29.9 Although the etiology and pathogenesis of BD, VKH syndrome, AAU, and BCR is not completely clear, the strong association with HLA and regional distribution of these diseases shows that immunogenetic predisposition is involved in the development of these diseases.
The immunopathogenesis of birdshot chorioretinopathy; a bird of many feathers
2015, Progress in Retinal and Eye ResearchDetection of choroid- and retina-antigen reactive CD8<sup>+</sup> and CD4<sup>+</sup> T lymphocytes in the vitreous fluid of patients with birdshot chorioretinopathy
2014, Human ImmunologyCitation Excerpt :More than 95% of BSCR patients have the HLA-A29 allele. To date this is documented as the strongest association between HLA and disease in humans [4,5]. While the strong HLA association suggests the involvement of autoreactive T cells in the pathophysiology of BSCR, a direct evidence for T cell involvement in BSCR is yet to be shown.
Reprint requests to H. A. Priem, M.D., Department of Ophthalmology, University of Gent, De Pintelaan 135, 9000 Gent, Belgium.