Analytical ReviewConsequence or coincidence?: The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines
Section snippets
Methods
All Medline records from 1966 through June of 2004 have been scanned and all articles relevant to vaccines (or immunizations) and safety, adverse reactions, autoimmune diseases or autoimmunity have been identified and all reports relating to viral vaccines were selected and retrieved. Additional searches were performed separately on each autoimmune disease or potentially autoimmune syndrome (e.g. SLE, arthritis, vasculitis, uveitis, thrombocytopenia, Guillain–Barre syndrome, etc.) and each one
Results
The findings regarding varied autoimmune manifestations reported in association with viral vaccines will be discussed separately for each of the vaccines studied.
Discussion
Vaccination can undoubtedly be counted among the most impressive achievements of modern medicine, saving millions of lives each year with relatively little cost and much safety [5]. Nevertheless, compliance has often been found to be very poor [90] and concern about adverse effects remains an important cause of noncompliance [91], though by no means the only one. Fuelled by the media and by groups of partially-informed activists [25], [92], the impression that viral vaccines may lead to the
Acknowledgments
The help of Professor Patrick Sissons, Head of the Department of Medicine at Addenbrooke's Hospital, whose advice and support were invaluable to me throughout this work — is gratefully acknowledged.
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