From bench to bedsidePilot assessment of a human extracellular matrix-based vascular graft in a rabbit model
Clinical Relevance
This preliminary study introduces the use of an allogeneic, cell-free, small-diameter vascular graft derived from the rolled human amniotic membrane. With this approach, graft diameter and wall thickness can be modulated to create conduits of specified dimensions. The ultimate goal is for the graft to integrate with native vasculature, allowing subsequent growth potential. Future work is needed to evaluate long-term remodeling and viability; however, in vivo investigation provides evidence that the layered scaffold can both mechanically withstand the stress of surgical implantation into native vasculature and subsequently support infiltration and early remodeling by host cell populations during 4 weeks.
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Financial support was provided by the National Institute of Health (NIH R01 HL088207).
Author conflict of interest: none.
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