Elsevier

Fertility and Sterility

Volume 90, Issue 5, November 2008, Pages 2016.e7-2016.e10
Fertility and Sterility

Case report
Pregnancy in a hermaphrodite with a male-predominant mosaic karyotype

https://doi.org/10.1016/j.fertnstert.2008.01.104Get rights and content
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Objective

To report a pregnancy in a hermaphrodite and review of the literature.

Design

Case report and literature review.

Setting

Clinical.

Patient(s)

A patient with male-predominant mosaic karyotype 96% 46XY.

Intervention(s)

Removal of left ovotestis in combination with a supracervical hysterectomy and bilateral salpingo-oophorectomy.

Main Outcome Measure(s)

Identification of published cases of pregnancy and hermaphroditism.

Result(s)

The current patient had previous pregnancy and a wedge biopsy of her left gonad, which demonstrated an ovotestis and an area suspicious for a gonadoblastoma. After delivery of her second pregnancy, the patient underwent a hysterectomy and bilateral salpingo-oophorectomy. The histopathologic evaluation following bilateral oophorectomy demonstrated a residual ovotestis without further evidence of a gonadoblastoma. Review of the literature identified 10 other cases of pregnancy in a hermaphrodite patient.

Conclusion(s)

This is the 11th reported case of fertility in a true hermaphrodite and only the second report of a mosaic true hermaphrodite to demonstrate fertility. This is the only case of a pregnancy involving a male-predominant mosaic 96% 46XY and the only case to confirm the genetics of the offspring.

Key Words

True hermaphrodite
pregnancy

Cited by (0)

S.A.S. has nothing to disclose. S.E.L. has nothing to disclose. P.S. has nothing to disclose. M.G.M. is a consultant for Ethicon Women's Health, Covidien, Gynesonics, Karl Storz Endoscopy, and AMAG Pharmaceuticals and is a shareholder in Gynesonics and Impres Medical. S.K. has nothing to disclose.