Current Biology
Volume 20, Issue 6, 23 March 2010, Pages R271-R274
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Meiosis: A PRDM9 Guide to the Hotspots of Recombination

https://doi.org/10.1016/j.cub.2010.01.048Get rights and content
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Summary

During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

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