Biochimica et Biophysica Acta (BBA) - Biomembranes
Volume 1848, Issue 10, Part B, October 2015, Pages 2703-2714
ReviewPotential applications for sigma receptor ligands in cancer diagnosis and therapy☆
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Graphical abstract
Use of sigma ligands for cancer diagnosis and treatment. Left panel: [11C]SA4503 scans of the brain of a healthy rat (A) and a rat with spontaneous pituitary tumor (B). Since sigma-1 receptors are strongly overexpressed in pituitary tumors, even very small tumors are clearly visualized in the scan. Right panel: Inhibition of the growth of a human melanoma xenograft in nude mice after daily treatment of animals with the sigma ligand rimcazole. Data taken from references [37] and [86].
Keywords
Antitumor agents
Chemotherapy
Drug targeting
Positron emission tomography
Sigma-1 receptor
Sigma-2 receptor
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This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
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