Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

doi:10.1016/S1074-5521(99)80107-0

Chemistry & Biology

Volume 6, Issue 9, September 1999, Pages R235-R240

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The molecular link between the signalling pathway regulating the formation of filopodia and the initiation of local actin polymerization has been elucidated: N-WASP, a close homologue of WASP, which is the product of the gene responsible for the Wiskott-Aldrich syndrome, mediates a direct connection between the small G-protein Cdc42 and the Arp2/3 complex.

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^*: Present Address: Laboratoire de Cristallographie et RMN Biologiques, CNRS, Faculté de Pharmacie, 75270 Paris, Cedex 06 France.