Hypoglycemia unawareness
References (34)
- et al.
Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes
Lancet
(1994) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
N Engl J Med
(1993)Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Lancet
(1999)- et al.
Hypoglycemia unawareness in Type I diabetic patients under conventional insulin treatment
Diab Nutr Metab
(1995) - et al.
Hypoglycemia in Diabetes
Diabetes Care
(2003) - et al.
Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms
J Clin Invest
(1987) - et al.
Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction
Am J Physiol
(1991) - et al.
Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans
Diabetologia
(1994) - et al.
Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics
N Engl J Med
(1988) - et al.
Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release
Diabetes
(1988)
Hypoglycemia-associated autonomie failure in advanced type 2 diabetes
Diabetes
Lack of glucagon response to hypoglycemia in diabetes. Evidence for an intrinsic pancreatic alpha cell defect
Science
Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion
Diabetes
Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomie response
Diabetes
Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to Hypoglycemia in Insulin-Deficient Diabetes
Diabetes
Hypoglycemia-associated autonomie failure in insulin-dependent diabetes mellitus
J Clin Invest
Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy
N Engl J Med
Cited by (37)
Hypoglycaemic unawareness: A systematic review of qualitative studies of significant others’ (SO) supportive interventions for patients with diabetes mellitus
2018, HeliyonCitation Excerpt :Anderbro et al., highlighted a complex relationship between hypoglycaemic episodes and fear and anxiety, showing that patients adopt strategies to avoid hypoglycaemic episodes (2010). Much of the research already available has a strong medical focus and explores the clinical interventions healthcare professionals could implement (Martin-Timon et al., 2015; Bakatselos, 2011). This literature is important for the treatment and management of the clinical condition, however Elliot and Rankin (2014) express concerns regarding the requirement to consider the psychological needs of both the patient and SO.
Hypoglycemia awareness among insulin-treated patients with diabetes in Malaysia: A cohort subanalysis of the HAT study
2017, Diabetes Research and Clinical PracticeCitation Excerpt :The responses ‘always’ and ‘usually’ indicate a normal awareness; i.e., knowing that hypoglycemia symptoms are associated with low blood sugar levels. The response ‘occasionally’ denotes impaired awareness, and ‘never’ denotes severely impaired awareness, whereby participants had impaired or complete loss of the ability to recognize or sense typical symptoms of hypoglycemia, which results from an impaired counter-regulatory mechanism and has been shown to increase the risk of future episodes of hypoglycemia [18,19]. Categories of hypoglycemia recorded in the questionnaire and patient diary included: non-severe hypoglycemia (defined as an event managed by the patient alone); severe hypoglycemia (defined, based on the American Diabetes Association definition, as any hypoglycemic event requiring assistance of another person to administer carbohydrate, glucagon or other resuscitative actions) [20]; and nocturnal hypoglycemia (any event occurring between midnight and 6:00 AM).
Coefficient of variation of R-R interval closely correlates with glycemic variability assessed by continuous glucose monitoring in insulin-depleted patients with type 1 diabetes
2015, Diabetes Research and Clinical PracticeCitation Excerpt :A deteriorated adrenalin response in type 1 diabetes is associated with an unawareness of hypoglycemia, and the hypoglycemic nadir is significantly lower in patients who are unaware than in patients who are aware [30]. Furthermore, hypoglycemia causes hypoglycemia-associated autonomic failure and a further defect of counterregulatory hormone secretion, leading to a vicious cycle of recurrent hypoglycemia [31–34]. In fact, CVR-R tended to be lower in patients with gastrointestinal dysmotility than in patients without it (2.44 ± 1.39 vs. 3.76 ± 1.88%, p = 0.062).
Hypoglycemia
2014, American Journal of MedicineCitation Excerpt :Those with recent antecedent hypoglycemia are predisposed.27,28 Affected individuals have loss of forewarning symptoms of hypoglycemia and decreased response to those symptoms, and thus are at increased risk of hypoglycemia.27,28 In one study, adults with type 1 diabetes and impaired awareness of hypoglycemia exhibited twice the frequency of all episodes of hypoglycemia over a 4-week monitoring period, compared with those with normal awareness (mean ± standard deviation, 7.9 ± 5.4 episodes vs 3.7 ± 3.6 episodes, P = .003).29
European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes
2023, Journal of NeuroendocrinologyEffects of Diabetes Mellitus-Related Dysglycemia on the Functions of Blood–Brain Barrier and the Risk of Dementia
2023, International Journal of Molecular Sciences