Elsevier

The Lancet

Volume 312, Issue 8099, 18 November 1978, Pages 1065-1068
The Lancet

STRONG ASSOCIATION BETWEEN MEMBRANOUS NEPHROPATHY AND HEPATITIS-B SURFACE ANTIGENÆMIA IN JAPANESE CHILDREN

https://doi.org/10.1016/S0140-6736(78)91801-9Get rights and content

Abstract

Renal histology in 163 Japanese children, aged 3 to 15, with proteinuria and/or hæmaturia showed that 11 had membranous nephropathy (M.N.) and the rest had various other renal diseases. Hepatitis-B-virus surface antigen (HBsAg) was identified, by a reversed passive hæmagglutination method, in the serum of all the patients with M.N. but in only 4·6% of the patients with other renal diseases. 6 of the 11 mothers of the children with M.N. were positive for HBsAg, and 1 was positive for antibody to HBsAg (anti-HBs). These findings suggest that M.N. in Japanese children is mainly, if not exclusively, caused by hepatitis-B virus and that in most instances the virus is transmitted from mother to child.

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