Elsevier

Tetrahedron Letters

Volume 38, Issue 16, 21 April 1997, Pages 2859-2862
Tetrahedron Letters

Callystatin A, a potent cytotoxic polyketide from the marine sponge, Callyspongia truncata

https://doi.org/10.1016/S0040-4039(97)00482-6Get rights and content

Abstract

Callystatin A (1) has been isolated from the marine sponge, Callyspongia truncata, and the plane structure, including parts of the absolute configurations, is elucidated. Callystatin A (1) is a novel polyketide with a terminal α,β-unsaturated δ-lactone and exhibited potent cytotoxicity against KB cells at IC50 0.01 ng/ml.

Callystatin A (1) has been isolated from the marine sponge Callyspongia truncata and the plane structure including parts of the absolute configurations elucidated. 1 exhibited potent cytotoxicity against KB cells.

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