Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human chromosomes Xq13-qter and 12q, respectively☆,☆☆
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Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity
2020, Cell ReportsCitation Excerpt :To investigate the pathophysiological role of macrophage-derived biglycan in HFHS diet-induced obesity, we generated chimeric mice in which biglycan is specifically deleted in myeloid cells. Since the Bgn gene is on the X chromosome (Chatterjee et al., 1993; McBride et al., 1990), male mice only have one copy. Thus, we chose to use male mice since it is easier to generate bone marrow-derived chimeric Bgn-deficient mice in males than females.
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2018, Matrix BiologyCitation Excerpt :Several studies have demonstrated a role for versican in pulmonary disorders and have been reviewed elsewhere [56]. Biglycan is a widely expressed proteoglycan that maps to the X chromosome [57]. It has an assembly role in the ECM, and disruption of the biglycan gene results in abnormal collagen fibril morphology [58].
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. JO4599.
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PGI (biglycan) and PGII (decorin) have been assigned the symbols BGN and DCN, respectively, by the Human Gene Nomenclature Committee.