Original contributionAcute fluoxetine overdose: A report of 234 cases☆
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Cited by (111)
Generalized seizures after acute fluoxetine overdose in four adolescents
2024, American Journal of Emergency MedicinePoisoning: Kinetics to Therapeutics
2019, Critical Care Nephrology: Third EditionSeizures and General Medical Disorders
2014, Aminoff's Neurology and General Medicine: Fifth EditionAntidepressant Overdose-induced Seizures
2013, Psychiatric Clinics of North AmericaFluoxetine suppresses synaptically induced [Ca<sup>2+</sup>]<inf>i</inf> spikes and excitotoxicity in cultured rat hippocampal neurons
2013, Brain ResearchCitation Excerpt :The inhibitory effect of fluoxetine at 3 μM was reversible after washout (87.8±6.6%, n=26). Therapeutic plasma concentrations of fluoxetine are reported to be about 0.15–1.5 μM (Orsulak et al., 1988), although plasma and brain concentrations of fluoxetine under certain conditions can reach higher levels (Borys et al., 1992; Karson et al., 1993). Therefore, we used fluoxetine at 2 μM to further investigate the underlying mechanism by which fluoxetine would inhibit the 0.1 mM [Mg2+]o-induced [Ca2+]i spikes in in vitro epilepsy models.
Antidepressant Overdose-induced Seizures
2011, Neurologic ClinicsCitation Excerpt :The seizure risk from escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline overdose is low. A prospective multicenter study that analyzed 87 cases of isolated fluoxetine ingestion reported no seizures.69 In a cohort study of 233 first admissions of deliberate self-poisoning with a single SSRI, seizures occurred in only 1.3% of patients.45
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Presented at the American Academy of Clinical Toxicology/American Association of Poison Control Centers/American Board of Medical Toxicology/Canadian Association of Poison Control Centers/Annual Scientific Meeting, held September 13–18, 1990 in Tucson, AZ.