Trends in Pharmacological Sciences
Volume 9, Issue 12, December 1988, Pages 437-438
The excitement of a suspense story, the beauty of a poem: the work of Hitchings and Elion
References (0)
Cited by (5)
Glutathione transferases in the bioactivation of azathioprine
2014, Advances in Cancer ResearchCitation Excerpt :Particular focus will be placed on human glutathione transferase A2-2 and molecular features that govern relationships between protein structure and catalytic activity with azathioprine. The thiopurine drugs 6-MP and 6-thioguanine were developed in the 1950s by George Hitchings and Gertrude B. Elion (Giner-Sorolla, 1988). Hitchings had theorized that antagonists of DNA bases might be able to inhibit the growth of rapidly dividing cells, and Elion screened several purine derivatives for the inhibition of purine utilization (Elion, 1989).
Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine
2008, Analytical BiochemistryStructural Determinants of Glutathione Transferases with Azathioprine Activity Identified by DNA Shuffling of Alpha Class Members
2008, Journal of Molecular BiologyDivergent activities of human glutathione transferases in the bioactivation of azathioprine
2006, Molecular PharmacologyA re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase
1994, The Histochemical Journal
Copyright © 1988 Published by Elsevier Ltd.