The excitement of a suspense story, the beauty of a poem: the work of Hitchings and Elion

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  • Glutathione transferases in the bioactivation of azathioprine

    2014, Advances in Cancer Research
    Citation Excerpt :

    Particular focus will be placed on human glutathione transferase A2-2 and molecular features that govern relationships between protein structure and catalytic activity with azathioprine. The thiopurine drugs 6-MP and 6-thioguanine were developed in the 1950s by George Hitchings and Gertrude B. Elion (Giner-Sorolla, 1988). Hitchings had theorized that antagonists of DNA bases might be able to inhibit the growth of rapidly dividing cells, and Elion screened several purine derivatives for the inhibition of purine utilization (Elion, 1989).

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