Original articleFatal spleen rupture during induction chemotherapy with RH GM-CSF priming for acute monocytic leukemia. Clinical case report and in vitro studies
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2022, Molecular Therapy Methods and Clinical DevelopmentCitation Excerpt :The observed histopathology changes are also consistent with previous reports showing that exposure of mice to high levels of mGM-CSF causes significant histopathological changes.36,37 Finally, rare case studies in humans have described splenic enlargement38 and rupture after recombinant GM-CSF treatment.39 Therefore, we next assessed the effect of lower viral titers.
Clinical and Ultrasonic Evaluation of Spleen Size during Peripheral Blood Progenitor Cell Mobilization by Filgrastim: Results of an Open-Label Trial in Normal Donors
2009, Biology of Blood and Marrow TransplantationCitation Excerpt :In a retrospective analysis from the International Bone Marrow Transplant Registry (IBMTR) and the European Blood and Marrow Transplant Group (EBMT), the incidence of serious complications was infrequent, occurring in 1% of 1488 donors receiving G-CSF for PBPC mobilization, with a safety profile that was comparable to BM harvesting. Within this experience, rare case reports of splenic rupture following G-CSF treatment have been reported [5-18]. Reported estimates of the incidence of splenic rupture vary in the literature from 0.08% [7,19] to approximately 1% [20].
Splenic rupture following lenograstim in post-autologous stem cell transplantation treated with emergency open splenectomy: a case report and literature review
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