Coincidence of seizure susceptibility to caffeine and to the benzodiazepine inverse agonist, DMCM, in SWR and CBA inbred mice
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Caffeine and seizures: A systematic review and quantitative analysis
2018, Epilepsy and BehaviorCitation Excerpt :In our quantitative analysis, we assessed the effect of caffeine on the antiepileptic potency of AEDs, whether this effect depends on the caffeine dose and differs between acute and chronic caffeine exposure. We also assessed the difference in sensitivity to the effects of caffeine, based on the mechanisms of action of the AEDs [8–12,67–80]. Our analysis shows a medium [ηp2 = 0.086] effect of caffeine on the ED50 of the tested AEDs when compared with their corresponding control groups.
The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy
2017, Epilepsy and BehaviorCitation Excerpt :The absence of this phenotype in other inbred strains facilitated its genetic dissection into multiple quantitative trait loci (QTL), each exerting a partial influence over seizure susceptibility in this model [71,72]. A wide variety of chemical agents have been utilized for comparing acute seizure susceptibility in different mouse strains, including traditional chemoconvulsants such as PTZ [73], picrotoxin [74], bicuculline [75], 3-mercaptopropionic acid [76], beta-carbolines [77,78], flurothyl [76], methionine sulfoximine [79], soman [80], kainic acid [81], isoniazid [60], and pilocarpine [82], as well as other drugs that are known to produce seizures clinically such as carbapenems [83], monobactams [84], anesthetic drugs [85], caffeine [77], cocaine [86], and nicotine [87]. Early studies established the relative susceptibility of DBA strains to chemoconvulsants compared to B6 strains [33], although DBA was reported to be one of the most resistant strains to nicotine-induced seizures [87].
Strain Effects on Expression of Seizures and Epilepsy
2017, Models of Seizures and Epilepsy: Second EditionPerspectives of zebrafish models of epilepsy: What, how and where next?
2012, Brain Research BulletinCitation Excerpt :As shown in Table 2, typical endpoints relevant to epilepsy in zebrafish include hyperactive, spiral or circular swimming, rapid twitching, spasm-like body contractions, loss of body posture, paralysis (immobility) and death. Several convulsant drugs, historically used in rodent models, include pentylenetetrazole (PTZ) [52], picrotoxin [56], pilocarpine [26], kainate [165] and caffeine [126]. These drugs also evoke robust seizure-like responses in larval and adult zebrafish (Table 1), ranging from initial hyperactivity to convulsions and loss of posture/paralysis [153] (Table 2).
Unexpected postpartum seizures associated with post-dural puncture headache treated with caffeine
1996, International Journal of Obstetric AnesthesiaThe use of pharmacogenetic techniques in drug abuse research
1992, Pharmacology and Therapeutics