Sigma receptor ligands alter concentrations of corticosterone in plasma in the rat
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Recent advances on the synthesis and application of tetrahydro-γ-carbolines
2023, Chinese Chemical LettersPheochromocytomas in Nf1 knockout mice express a neural progenitor gene expression profile
2007, NeuroscienceCitation Excerpt :Down-regulated genes might also provide clues to currently unrecognized functions of normal chromaffin cells in which those genes are expressed. For example, sigma opioid receptors (down 4.95-fold) are neuronal genes normally involved in hypothalamic feedback control of corticosterone secretion (Matheson et al., 1991). Their expression in chromaffin cells could reflect a new mechanism of cortical/medullary interaction (Schinner and Bornstein, 2005).
The neurobiology and control of anxious states
2003, Progress in NeurobiologyCitation Excerpt :Of special note is the observation that anxiolytic actions of glycineB partial agonists persist following their prolonged administration, in line with findings in other models (Skolnick et al., 1992; Przegaliński et al., 1999). Likewise in accordance with results acquired with recognition site antagonists and open channel blockers (Section 3.2.2), it has been shown that glycineB sites in the hippocampus participate in the anxiolytic actions of the partial agonist, ACPC, in the VCT, while observations with other paradigms suggest a prominent role for glycineB sites in the PAG (Table 7 and Fig. 3) (Matheus et al., 1994; Przegaliński et al., 1996; De Souza et al., 1998). Ionotropic, heteromeric, cation-permeable AMPA receptors are composed of four subunits (GluR1–4), of which their “flop” as compared to their alternatively-spliced “flip” isoforms predominate in adult CNS (Sommer et al., 1990; Bleakman and Lodge, 1998).
Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression
1997, Brain ResearchNeuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and σ receptors
1994, European Journal of Pharmacology