Hypercalciuria and altered intestinal calcium absorption occurring independently of vitamin D in incomplete distal renal tubular acidosis☆,☆☆
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Cited by (39)
Renal stone disease, hypercalciuria, and osteoporosis: Use of thiazides and alkali for osteoporosis
2020, Marcus and Feldman’s OsteoporosisIncomplete Distal Renal Tubular Acidosis and Kidney Stones
2018, Advances in Chronic Kidney DiseaseCitation Excerpt :Mechanistically, rate- or capacity-limited distal tubular H+ secretion is the reason for reduced urinary net acid excretion and alkaline urinary pH.25 Unlike in pRTA, there is systemic H+ retention in patients with type I dRTA.3,4 As a consequence of H+ retention, intestinal calcium absorption and release of calcium from bone increase and renal calcium reabsorption decreases, resulting in hypercalciuria.26-28 Hypocitraturia due to avid reclamation of citrate by proximal tubular cells in the setting of systemic acidosis is another hallmark of type I dRTA.
Nephrolithiasis-associated bone disease: Pathogenesis and treatment options
2011, Kidney InternationalCitation Excerpt :There has been no study using bone histomorphometry and dual-energy x-ray absorptiometry to link bone disease to patients with distal renal tubular acidosis and kidney stones. However, in a short-term metabolic study, negative calcium balance was corrected with potassium alkali treatment in patients with incomplete distal renal tubular acidosis.35 In one study, in both male and female patients with osteoporosis, the prevalence of incomplete distal renal tubular acidosis was reported to be as high as 44% in men and 20% in premenopausal women.36
The Acid-Base Effects of the Contemporary Western Diet: An Evolutionary Perspective
2008, Seldin and Giebisch's The KidneyThe Acid-Base Effects of the Contemporary Western Diet. An Evolutionary Perspective.
2007, Seldin and Giebisch's The Kidney: Physiology & Pathophysiology 1-2
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Supported by grants from USPHS (PO1-AM20543, RO1-AM16061, MO1-RR00633, and 5T32-AM07307) and by the American Urological Association Research Scholarship.
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Presented at the Annual Meeting of the American Urological Association, held in New Orleans, May 1984.