Biochemical and Biophysical Research Communications
Molecular cloning of the human brain and gastric cholecystokinin receptor: Structure, functional expression and chromosomal localization☆
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Differential effects of cholecystokinin (CCK-8) microinjection into the ventrolateral and dorsolateral periaqueductal gray on anxiety models in Wistar rats
2018, Hormones and BehaviorCitation Excerpt :The vast majority of CCK receptors in the central nervous system are of the CCK2 type (Moran et al., 1986; Noble and Roques, 2006), while CCK1 receptors are restricted to some brain structures including the interpeduncular nucleus, area postrema, nucleus tractus solitarius, and hypothalamus (Honda et al., 1993; Innis and Snyder, 1980). CCK receptors are activated by the endogenous peptides CCK-8 (CCK, P06307), CCK-33 (CCK, P06307), CCK-58 (CCK, P06307) and gastrin (GAST, P01350) (Pisegna et al., 1992). Both CCK receptors are G-protein coupled receptor (GPCR) coupled to the Gq/PLC pathway (Lee and Soltesz, 2010; Noble and Roques, 2006).
The investigation of membrane binding by amphibian peptide agonists of CCK2R using <sup>31</sup>P and <sup>2</sup>H solid-state NMR
2014, PeptidesCitation Excerpt :None of these peptides is membrane active; i.e. they do not penetrate and destroy the membrane lipid bilayer (e.g. they do not show antibiotic, anticancer, antifungal or antiviral activity of enveloped viruses cf. [9]). Each of the three named skin peptides acts via the cholecystokinin 2 receptor (CCK2R) [6,25,39,42]. CCK2 receptors are part of a large family of G-protein coupled receptors, located on the exterior membrane of cells.
The role of cholecystokinin receptors in the short-term control of food intake
2013, Progress in Molecular Biology and Translational ScienceCitation Excerpt :The cDNA encoding the CCK2 receptor, a clone that encodes 453 amino acids, was first identified by Kopin and colleagues using a COS-7 cell line.112 This finding was confirmed in brain and gastric tissues.94,113,114 There is approximately a 50% sequence homology between the CCK1 and the CCK2 receptors.
Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin. Gastrin, Cholecystokinin, Somatostatin, and Ghrelin
2012, Physiology of the Gastrointestinal Tract, Two Volume SetSingle-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
2012, CellCitation Excerpt :Among the mutated genes in this ccRCC patient, TUBB is potentially interesting, as it plays a role in structure maintenance (Hall et al., 1983); the truncating somatic mutation that we identified in six cancer cells could result in abnormal microtubule development and could conceivably contribute to the instability of cancer cells. The CCKBR gene, mutated in 12 cells, may also be of interest for future study, as it encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK) (Pisegna et al., 1992). These regulatory peptides of the brain and gastrointestinal tract had a miss-spliced transcript variant, including an intron observed in cells from colorectal and pancreatic tumors (Caplin et al., 2000; Yu et al., 2006).
Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin
2012, Physiology of the Gastrointestinal Tract
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. L04473.