A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas

https://doi.org/10.1016/0006-291X(86)90708-4Get rights and content

Abstract

Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).

References (23)

  • K. Sletten et al.

    J. Exp. Med

    (1976)
  • F. Gejyo et al.

    Biochem. Biophys. Res. Commun

    (1985)
  • E.D. Eanes et al.

    J. Histochem. Cytochem

    (1968)
  • G.G. Glenner et al.

    J. Histochem. Cytochem

    (1974)
  • G.G. Glenner

    New Engl. J. Med

    (1980)
    G.G. Glenner

    New Engl. J. Med

    (1980)
  • G.G. Glenner et al.

    Science

    (1971)
  • E.P. Benditt et al.

    FEBS Lett

    (1971)
  • P.P. Costa et al.
  • D.H. Cohen et al.

    J. Exp. Med

    (1983)
  • G.G. Glenner et al.

    Biochem. Biophys. Res. Commun

    (1984)
  • G.G. Cornwell et al.

    J. clin. Path

    (1980)
  • Cited by (439)

    View all citing articles on Scopus
    View full text