Biochimica et Biophysica Acta (BBA) - Enzymology
Separation of multiple molecular forms of cyclic adenosine-3′,5′-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis
References (25)
- et al.
J. Biol. Chem.
(1962) - et al.
J. Biol. Chem.
(1970) - et al.
J. Biol. Chem.
(1971) - et al.
Biochem. Biophys. Res. Commun.
(1970) - et al.
Biochem. Biophys. Res. Commun.
(1971) Biochem. Biophys. Res. Commun.
(1967)Biochem. Biophys. Res. Commun.
(1970)- et al.
Anal. Biochem.
(1972) J. Biol. Chem.
(1971)- et al.
J. Biol. Chem.
(1951)
Biochemistry
Biochemistry
Cited by (136)
Current trends in Hedgehog signaling pathway inhibition by small molecules
2018, Bioorganic and Medicinal Chemistry LettersCitation Excerpt :Despite these preclinical findings, it is worth mentioning that caution needs to be taken to target PDE4 for cancer treatment. Indeed, PDE4 has four subtypes (PDE4A, PDE4B, PDE4C, and PDE4D),59,60 whose roles in cancer progression should be carefully understood in order to develop subtype-specific inhibitors for the safe and efficient treatment of Hh-dependent tumors. The dual-specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK) family has been shown to positively and negatively regulate Hh signaling and to have oncogenic functions in Hh-related solid tumors.61
The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics
2017, Journal of the American College of CardiologyCitation Excerpt :Another class of NOsGC-cGMP pathway modulators is the phosphodiesterases. These enzymes inhibit the pathway by hydrolyzing the phosphodiester bond of cGMP (178,205). There are 4 phosphodiesterase 5 inhibitors in current clinical use that inhibit cGMP breakdown: sildenafil, vardenafil, tadalafil, and avanafil.
Distribution of PDE8A in the nervous system of the Sprague-Dawley rat
2011, Journal of Chemical NeuroanatomyCitation Excerpt :The cyclic nucleotide phosphodiesterases (PDEs) comprise a group of enzymes which hydrolyze the second messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP); such PDEs being important modulators of cyclic nucleotide mediated signal transduction (Beavo, 1995). The enzymes were isolated from rat brain in the early 1970s (Strada et al., 1974; Uzunov and Weiss, 1972). PDEs regulate the localization, duration and amplitude of cyclic nucleotide signaling within subcellular domains (Baillie et al., 2005; Cooper, 2005; Wilson et al., 2008).
Calmodulin transcription is limited to the nervous system during Drosophila embryogenesis
1992, Developmental BiologyInsulin control of cyclic AMP phosphodiesterase
1989, Life Sciences
- ∗
Present address: Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, Pa. 19129.