Extracellular Matrix of the Human Optic Nerve Head
References (19)
- et al.
Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma
Am. J. Ophthalmol.
(1983) - et al.
The multiple types and forms of collagen
Methods Enzymol.
(1982) - et al.
Laminin. A glycoprotein from basement membranes
J. Biol. Chem.
(1979) The extracellular matrix of the nervous systems
Trends Neurosci.
(1984)- et al.
Pathogenesis of optic nerve damage and visual field defects.
The pathogenesis of visual field loss in glaucoma.
- et al.
Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve
Invest. Ophthalmol.
(1974)
Cited by (62)
Engineering a 3D hydrogel system to study optic nerve head astrocyte morphology and behavior
2022, Experimental Eye ResearchLaminar and Prelaminar Tissue Characteristics of Glaucomatous Eyes Using Enhanced Depth Imaging OCT
2021, Ophthalmology GlaucomaCitation Excerpt :In addition to the LC, the PLT may influence glaucomatous optic nerve damage.20 The prelaminar region is composed of bundles of optic nerve fibers, astrocytes, capillaries, and extracellular material2,35 that may become thinned by ischemia.36 Ocular blood flow plays a main role in the pathogenesis of glaucomatous optic nerve damage, and blood flow velocities are decreased in choroidal vessels37 and the carotid artery38 in pseudoexfoliation syndrome (PXF)–affected eye as compared with unaffected fellow eyes.
Microstructure and resident cell-types of the feline optic nerve head resemble that of humans
2021, Experimental Eye ResearchCitation Excerpt :Within the human and non-human primate ONH, are three distinct sub-regions: pre-laminar (PL); lamina cribrosa (LC), and retro-laminar (RL) (Anderson, 1969; Minckler et al., 1976; Balaratnasingam et al., 2009), each with distinct functions and resident cell populations and differing patterns of axonal cytoskeletal protein expression (Balaratnasingam et al., 2009; Kang and Yu, 2015). It has been proposed that this marked heterogeneity between ONH sub-regions in their ECM composition (Hernandez et al., 1986; Goldbaum et al., 1989; Morrison et al., 1995), cell-type, microvasculature (Kang et al., 2018), myelination (Anderson, 1969; Elkington et al., 1990), mitochondrial activity (Bristow et al., 2002; Barron et al., 2004) and axonal structural components (Kang et al., 2014), may play a key role in determining regional vulnerability to injury and disease. In particular, a growing body of evidence supports the involvement of multiple resident cell types of the ONH in glaucoma pathobiology (Nickells et al., 2012; Williams et al., 2017).
The extracellular matrix composition of the optic nerve subarachnoid space
2020, Experimental Eye ResearchCitation Excerpt :This will have direct consequences for optic nerve homeostasis and might thus as well play a role in the pathogenesis of certain optic neuropathies such a glaucoma and papilledema (Hernandez et al., 1986, 1989, 1990).
A novel hypothesis for the pathogenesis of glaucomatous disc hemorrhage
2017, Progress in Retinal and Eye ResearchCitation Excerpt :In the prelaminar ONH, capillaries are surrounded by connective tissue sheaths including collagen IV, elastic fibers, and glial columns formed by astrocytes (Anderson, 1969; Hernandez, 2000; Tektas et al., 2010). In the LC, collagen type IV, laminin and elastin constitute the majority, and the former two are localized in the BM of blood vessels and astrocytes (Hernandez et al., 1986; Morrison et al., 1989a, 1989b). These structures form laminar beams, with capillaries in the core, surrounded by astrocytes and supportive connective tissues (Anderson, 1969).
Life under pressure: The role of ocular cribriform cells in preventing glaucoma
2016, Experimental Eye Research
This study was supported in part by Public Health Service grant EY-02367. This study was presented in part at the Glaucoma Update, Palm Springs, California, Feb. 22, 1986.
Reprint requests to Arthur H. Neufeld, Ph.D., Eye Research Institute, 20 Staniford St., Boston, MA 02114.