Clinical study
Genetic aspects of adenomatosis of endocrine glands

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Abstract

  • 1.

    1. The syndrome of adenomatosis of the anterior pituitary, the parathyroids and the pancreatic islets was observed in a family in which the father and four of nine siblings were affected. It is assumed that the syndrome in this family was caused by a dominant autosomal gene with a high degree of penetrance.

  • 2.

    2. The gross and microscopic findings in the parathyroids and in the pancreas differ from those seen in the more common single adenomas. The therapeutic approach therefore has to be different in the two types of cases.

  • 3.

    3. Peptic ulcers of the stomach and of the duodenum are frequently found in patients suffering from the syndrome of adenomatosis of the endocrine gland. This may be looked upon as another manifestation of the abnormal gene.

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1

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York, N. Y.

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