Abstract
Introduction
Osteoporosis is a debilitating silent disease with a huge socio-economic impact. Prevention strategies and early detection of osteoporosis need to be carried out in every health care unit to substantially reduce the fracture rates. Indian studies have indicated a knowledge gap on diagnosis and management of osteoporosis amongst medical professionals and consumers.
Areas Covered
This article reviews the evidences available on searches from PubMed and The National Library of Medicine, author's opinions based on clinical experience. There is a need for escalating the efforts to bridge the knowledge gap regarding various aspects of osteoporosis amongst professionals and consumers. Three indications for postmenopausal hormone therapy (HT), which have constantly withstood the test of time, are symptom relief, urogenital atrophy, and bone health. This article specifically focuses on management of postmenopausal osteoporosis by HT alone or in combinations.
Expert Opinion
Early menopause is within 10 years of menopause and late menopause is considered beyond 10 years of menopause. HT is a cost-effective therapy in the early post menopause especially in symptomatic women at risk for osteoporosis unless contraindicated. HT prevents all osteoporotic fractures even in low-risk population. All HT preparations including low dose and non-oral routes of estrogen are effective for bone health. The bone protective effect lasts while on HT. Extended use of HT in women after 10 years of menopause with reduced bone mass is an option after detailed counselling of the risk benefit analysis compared with the other available therapies for osteoporosis. The primary therapy to prevent bone loss in women with premature menopause and secondary amenorrhea is HT. HT work up and annual follow-up is essential before prescribing HT.
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References
(1991). Consensus development conference: prophylaxis and treatment of osteoporosis. The American Journal of Medicine, 90, 107-110.
Siris, E. S., Miller, P. D., Barret-Conner, E., et al. (2001). Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: Results from the National Osteoporosis Risk Assessment. JAMA, 286, 2815–2822.
National Osteoporosis Foundation. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Available from: http://www.nof.org/professionals/clinical-guidelines. Accessed 13 Jan 2011.
Cooper, C., Campion, G., & Melton, L. J., 3rd. (1992). Hip fractures in the elderly: A world-wide projection. Osteoporosis International, 2, 285–289.
Kado, D. M., Browner, W. S., Palermo, L., Nevitt, M. C., Genant, H. K., & Cummings, S. R. (1999). Vertebral fractures and mortality in older women: A prospective study. Study of Osteoporotic Fractures Research Group. Archives of Internal Medicine., 159, 1215–1220.
Melton, L. J., III. (1993). Hip fractures: A worldwide problem today and tomorrow. Bone, 14, 1–8.
Meeta, M., Harinarayan, C. V., Marwah, R., Sahay, R., Kalra, S., & Babhulkar, S. (2020). Clinical practice guidelines on postmenopausal osteoporosis: Indian menopause society. Journal of Mid-life Health., 11, 96.
Dhanwal, D. K., Siwach, R., Dixit, V., Mithal, A., Jameson, K., & Cooper, C. (2013). Incidence of hip fracture in Rohtak district, North India. Archives of Osteoporosis, 8(1–2), 135.
Marwaha, R. K., Tandon, N., Gupta, Y., Bhadra, K., Narang, A., Mani, K., Mithal, A., & Kukreja, S. (2012). The prevalence of and risk factors for radiographic vertebral fractures in older Indian women and men: Delhi Vertebral Osteoporosis Study (DeVOS). Archives of Osteoporosis, 7, 201–207. https://doi.org/10.1007/s11657-012-0098-8. Epub 2012 Sep 18 PMID: 23225298.
Mithal, A., & Kaur, P. (2012). Osteoporosis in Asia: A call to action. Current Osteoporosis Reports, 10(4), 245–247.
Shatrugna, V., KulkarniKumar, B. P. A., et al. (2005). Bone status of Indian Women from a low income group and it’s relationship to the nutritional status. Osteoporosis International, 16, 1827.
Gupta, A. (1998). Osteoporosis in India—the nutritional hypothesis. In A. Mithal, D. S. Rao, & M. Zaidi (Eds.), Metabolic bone disorders (p. 115). Hindustani Book Depot.
Thakur, P., Kuriakose, C., Cherian, K. E., Asha, H. S., Kapoor, N., & Paul, T. V. (2020). Knowledge gap regarding osteoporosis among medical professionals in Southern India. Journal of Evaluation in Clinical Practice, 26, 272–280. https://doi.org/10.1111/jep.13164
Senthilraja, M., Cherian, K. E., Jebasingh, F. K., Kapoor, N., Paul, T. V., & Asha, H. S. (2019). Osteoporosis knowledge and beliefs among postmenopausal women: A cross-sectional study from a teaching hospital in southern India. J Family Med Prim Care, 8, 1374–1378.
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004). Androgens and bone. Endocrine Reviews, 25, 389–425.
Albright, F., Smith, P. H., & Richardson, A. M. (1941). Postmenopausal osteoporosis: Its clinical features. JAMA, 116, 2465–2474.
Gambacciani, M., Spinetti, A., Taponeco, F., Cappagli, L., & Fioretti, P. (1994). Longitudinal evaluation of perimenopaausal vertebral bone loss: Effects of a low-dose oral contraceptive preparation on bone mineral density and metabolism. Obstetrics and Gynecology, 83, 392–396.
Gambacciani, M., Spinetti, A., Taponeo, F., Taponeco, F., Manetti, P., Piaggesi, L., et al. (1994). Bone loss in perimenopusal women: a longitudinal study. Maturitas, 18, 191–197.
Aebi, S., Davidson, T., Gruber, G., Castiglione, M., ESMO Guidelines Working Group. (2010). Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 21(Suppl 5), v9-14.
Hadji, P. (2009). Aromatase inhibitor-associated bone loss in breast cancer patients is distinct from postmenopausal osteoporosis. Critical Reviews in Oncology Hematology, 69, 73–82.
Hadji, P., Aapro, M. S., Body, J. J., Bundred, N. J., Brufsky, A., Coleman, R. E., Gnant, M., et al. (2011). Management of aromatase inhibitor-associated bone loss in postmenopausal women with breast cancer: Practical guidance for prevention and treatment. Annals of Oncology, 22, 2546–2555.
Seifert-Klauss, V., Mueller, J. E., Luppa, P., Probst, R., Wilker, J., Höss C, et al. (2002). Bone metabolism during the perimenopausal transition: a prospective study. Maturitas, 41, 23–33.
Guthrie, J. R., Ebeling, P. R., Hopper, J. L., Barrett-Connor, E., Dennerstein, L., Dudley, E. C., et al. (1998). A prospective study of bone loss in menopausal Australian-born women. Osteoporosis International, 8, 282–290.
Tanko, L. B., & Christianson, C. (2006). Hormone replacement therapy. In A. R. Genazzani (Ed.), Postmenopausal osteoporosis: hormones and other therapies. Controversial issues in climacteric medicine series (pp. 186–187). CRC Press.
Khastgir, G., Studd, J., Holland, N., Alaghband-Zadeh, J., Fox, S., & Chow, J. (2001). Anabolic effects of estrogen replacement on bone replacement in postmenopausal women with osteoporosis: Histomorphometric evidence in a longitudinal study. Journal of Clinical Endocrinology and Metabolism, 86, 289–295.
Cummings, S. R., Browner, W. S., Bauer, D., Stone, K., Ensrud, K., Jamal, S., & Ettinger, B. (1998). Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. New England Journal of Medicine., 339(11), 733–738. https://doi.org/10.1056/NEJM199809103391104. PMID: 9731089.
Forbes, A. P. (1991). Fuller Albright. His concept of postmenopausal osteoporosis and what came of it. Clinical Orthopaedics and Related Research., 269, 128–141.
Marcus, R., Holloway, L., Wells, B., Greendale, G., James, M. K., Wasilauskas, C., et al. (1999). The relationship of biochemical markers of bone turnover to bone density changes in postmenopausal women: results from the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial. Journal of Bone and Mineral Research., 14, 1583–1595.
Wells, G., Tugwell, P., Shea, B., et al. (2002). Meta-analyses of therapies for postmenopausal osteoporosis. V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women. Endocrine Review, 23, 529–539.
Rossouw, J. E., Anderson, G. L., Prentice, R. L., et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women’s Health Initiative randomized controlled trial. JAMA, 288, 321–333.
Torgerson, D. J., & Bell-Syer, S. E. M. (2001). Hormone replacement therapy and prevention of nonvertebral fractures: A meta-analysis of randomized trials. JAMA, 285(22), 2891–2897. https://doi.org/10.1001/jama.285.22.2891
Marjoribanks, J., Farquhar, C., Roberts, H., & Lethaby, A. (2012). Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database of Systematic Reviews (7), CD004143
Lorentzon, M., Johansson, H., & Harvey, N. C. (2023). Menopausal hormone therapy reduces the risk of fracture regardless of falls risk or baseline FRAX probability—results from the Women’s Health Initiative hormone therapy trials. Osteoporosis International. https://doi.org/10.1002/14651858.CD004143.pub4.Accessed24June
Goldštajn, M. Š, Mikuš, M., Ferrari, F. A., Bosco, M., & U,. (2023). Effects of transdermal versus oral hormone replacement therapy in postmenopause: A systematic review. Archives of Gynecology and Obstetrics, 307(6), 1727–1745. https://doi.org/10.1007/s00404-022-06647-5
Lindsay, R., Gallagher, C., Kleerekoper, M., et al. (2002). Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women. JAMA, 287, 2668–2676.
Cummings, S. R., Ettinger, B., Delmas, P. D., Kenemans, P., Stathopoulos, V., Verweij, P., Mol-Arts, M., Kloosterboer, L., Mosca, L., Christiansen, C., Bilezikian, J., Kerzberg, E. M., Johnson, S., Zanchetta, J., Grobbee, D. E., Seifert, W., & Eastell, R. (2008). LIFT Trial Investigators: The effects of tibolone in older postmenopausal women. New England Journal of Medicine, 359, 697–708. https://doi.org/10.1056/NEJMoa0800743
Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. (1998). Lancet, 351, 1451–1467.
Grady, D., Ettinger, B., Moscarelli, E., Multiple Outcomes of Raloxifene Evaluation Investigators, et al. (2004). Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluation. Obstetrics & Gynecology., 104, 837–844.
Lobo, R. A., Pinkerton, J. V., Gass, M. L. S., et al. (2009). Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic bone parameters and overall safety profile. Fertility and Sterility, 92, 1025–1038.
Genant, H. K. (2011). Bazedoxifene: A new selective estrogen receptor modulator for postmenopausal osteoporosis. Menopause International, 17, 44–49.
Yoon, B. K., Lee, D. Y., Park, M. C., Cho, S. H., Park, H. M., & Choi, Y. M. (2017). Effects of combination therapy of alendronate and hormonal therapy on bone mineral density in postmenopausal Korean women: Multicenter, randomized controlled clinical trial. Journal of Korean Medical Science., 32(6), 992–998.
Simonelli, C., Adler, R. A., Blake, G. M., Caudill, J. P., Khan, A., Leib, E., Maricic, M., Prior, J. C., Eis, S. R., Rosen, C., & Kendler, D. L. (2008). Dual-energy X-Ray absorptiometry technical issues: The 2007 ISCD Official Positions. Journal of Clinical Densitometry., 11(1), 109–122. https://doi.org/10.1016/j.jocd.2007.12.009. PMID: 18442756.
Singh, M. (2012). Early age of natural menopause in India, a biological marker for early preventive health programs. Climacteric, 15, 581–586.
Shatrugna, V., Kulkarni, B., Kumar, P. A., Rani, K. U., & Balakrishna, N. (2020). Bone status of Indian women from a low-income group and its relationship to the nutritional status. Osteoporosis International., 31(2), 251–257.
Merlijn, T., Swart, K. M. A., van der Horst, H. E., et al. (2020). Fracture prevention by screening for high fracture risk: a systematic review and meta- analysis. Osteoporosis International., 31(2), 251–257.
Jackson, R. D., Wactawski-Wende, J., LaCroix, A. Z., Pettinger, M., Yood, R. A., Watts, N. B., Women’s Health Initiative Investigators, et al. (2006). Effects of conjugated equine estrogen on risk of fractures and BMD in postmenopausal women with hysterectomy: results from the women’s health initiative randomized trial. Journal of Bone and Mineral Research., 21, 817–828.
Cauley, J. A., Robbins, J., Chen, Z., Cummings, S. R., Jackson, R. D., LaCroix, A. Z., Women’s Health Initiative Investigators, et al. (2003). Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Women’s Health Initiative randomized trial. JAMA, 290, 1729–1738.
Huang, A. J., Ettinger, B., Vitinghoff, E., Ensrud, K. E., Johnson, K. C., & Cummings, S. R. (2007). Endogenous estrogen levels and the effects of ultra- low-dose Transdermal estradiol on bone turnover and BMD in postmenopausal women. Journal of Bone and Mineral Research, 22, 1791–1797.
Heiss, G., Wallace, R., Anderson, G. L., Aragaki, A., Beresford, S. A., Brzyski, R., WHI Investigators, et al. (2008). Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA, 299, 1036–1045.
LaCroix, A. Z., Chlebowski, R. T., Manson, J. E., Aragaki, A. K., Johnson, K. C., Martin, L., WHI Investigators, et al. (2011). Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA, 305, 1305–1314.
Dören, M., Nilsson, J. A., & Johnell, O. (2003). Effects of specific post-menopausal hormone therapies on bone mineral density in post-menopausal women: A meta-analysis. Human Reproduction, 18, 1737–1746.
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Rani, J., Swati, S., Meeta, M. et al. Postmenopausal Osteoporosis: Menopause Hormone Therapy and Selective Estrogen Receptor Modulators. JOIO 57 (Suppl 1), 105–114 (2023). https://doi.org/10.1007/s43465-023-01071-6
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DOI: https://doi.org/10.1007/s43465-023-01071-6