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Metabolic Syndrome and Its Effects on Cartilage Degeneration vs Regeneration: A Pilot Study Using Osteoarthritis Biomarkers

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Abstract

Background

Osteoarthritis (OA) of the knee is one of the leading causes of disability characterized by degeneration of hyaline cartilage combined with reparative processes. Its strong association with metabolic syndrome is postulated to be due to both mechanical and biochemical factors. Our study aims to study differential effect of metabolic risk factors on cartilage degeneration and regeneration at biomarker level.

Design

After screening 281 patients presenting with knee pain, 41 patients who met the selection criteria were included and were divided into metabolic (MetS) OA and non-metabolic (Non-MetS) OA phenotypes using National Cholesterol Education Programme—Adult Treatment Panel—III (NCEP-ATP-III) criteria for metabolic syndrome. Serum Cartilage Oligomeric Matrix Protein (COMP) and Procollagen type IIA N terminal Propeptide (PIIANP) levels were used as tools to assess cartilage degeneration and regeneration, respectively.

Results

22 among 41 patients (53.66%) had metabolic syndrome. Covariates like age, gender, Kellgren Lawrence (KL) grades were comparable in both groups. MetS-OA group showed significant increase in serum COMP levels (p = 0.03) with no significant effect on serum PIIANP levels (p = 0.46). Hypertriglyceridemia showed independent association with both cartilage anabolism (p = 0.03) and catabolism (p = 0.03).

Conclusion

Metabolic syndrome, though has no effect on cartilage regeneration tends to shift cartilage homeostasis towards degeneration with hypertriglyceridemia showing significant independent effect on cartilage metabolism.

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Authors and Affiliations

  1. Department of Orthopaedics, PGIMER, Chandigarh, 160012, India

    Rajath Siddaramanna Onkarappa

  2. Department of Orthopaedics, PGIMER, Chandigarh, India

    Rajath Siddaramanna Onkarappa, Devendra Kumar Chauhan & Rajendra Kumar Kanojia

  3. PGIMER, Sector 12, Chandigarh, 160012, India

    Biman Saikia & Adil Karim

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  1. Rajath Siddaramanna Onkarappa
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  2. Devendra Kumar Chauhan
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  3. Biman Saikia
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  5. Rajendra Kumar Kanojia
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Correspondence to Rajendra Kumar Kanojia.

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Onkarappa, R.S., Chauhan, D.K., Saikia, B. et al. Metabolic Syndrome and Its Effects on Cartilage Degeneration vs Regeneration: A Pilot Study Using Osteoarthritis Biomarkers. JOIO 54 (Suppl 1), 20–24 (2020). https://doi.org/10.1007/s43465-020-00145-z

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  • DOI: https://doi.org/10.1007/s43465-020-00145-z

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