Abstract
The search for new molecules with biochemical and pharmacological efficacy has led scientists to investigate a very wide range of natural or synthetic compounds and also extracts rich in bioactive compounds. Since the seventies, several studies have focused on the biological potential of carvone and carvotanacetone and their derivatives, isolated from natural extracts or synthesized by chemical methods. This review summarizes the different findings reached so far regarding the biosynthesis and biological activities demonstrated for these molecules. Carvone and carvotanacetone are monoterpene ketones synthesized by the methylerythritol phosphate pathway in plastids via geranyl-pyrophosphate through an intermediate like limonene or β-pinene in some microorganisms and plants. Carvone and carvotanacetone derivatives have been obtained from natural extracts, biotransformation by microorganisms, or organic synthesis. These molecules and their derivatives have shown interesting antioxidant, antimicrobial, anti-inflammatory, cytotoxic, antiproliferative, chemopreventive, antispasmodic, antiulcer, anticonvulsant, antinociceptive, antiparasitic, larvicidal, and insecticidal activities. The prospects for the pharmacological exploitation of these molecules will be promising and will allow the emergence of potent alternatives to conventional therapeutical principles.
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References
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DT was responsible for the study’s design and writing. FE, CM, HN, MO, and MY reviewed the manuscript. All the authors have approved the manuscript.
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Tahri, D., Elhouiti, F., Chelghoum, M. et al. Biosynthesis and Biological Activities of Carvone and Carvotanacetone Derivatives. Rev. Bras. Farmacogn. 32, 708–723 (2022). https://doi.org/10.1007/s43450-022-00302-5
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DOI: https://doi.org/10.1007/s43450-022-00302-5