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Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis

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Abstract

The objective of this study is to investigate whether kisspeptin levels in early pregnancy have a better diagnostic value on early pregnancy outcome as compared with human chorionic gonadotropin (hCG). This study was a systematic review and meta-analysis aiming to investigate the diagnostic value of kisspeptin levels on early pregnancy outcome. The primary outcome was miscarriage or viable intrauterine pregnancy. Five studies were included for systematic review, and three studies were included for meta-analysis. Meta-analysis showed kisspeptin levels had a good diagnostic value with the area under the curve (AUC) 0.902 (0.866, 0.937) when kisspeptin was measured after 6 weeks of gestation. Sensitivity analysis demonstrated kisspeptin levels had a diagnostic value with AUC = 0.881 (0.855, 0.906). hCG levels had a diagnostic value with AUC = 0.834 (0.785, 0.883), which was inferior to the diagnostic value of kisspeptin (mean difference = 0.09 (0.02, 0.16)). Kisspeptin measurement has a potential for comparable or even higher accuracy than hCG in differentiating between miscarriage and viable intrauterine pregnancy after 6 weeks of gestation.

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All data generated or analysed during this study are included in this published article.

Abbreviations

AUC:

Area under the curve

hCG:

Human chorionic gonadotropin

CIs:

Confidence intervals

SE:

Standard error

sROC:

Summary receiver operating characteristic

RIA:

Radioimmunoassay

ELISA:

Enzyme-linked immunosorbent assay

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Funding

This study was supported by grants from National Natural Science Foundation of China (81873835 and 82071726).

Author information

Authors and Affiliations

  1. Center for Reproductive Medicine, Peking University Third Hospital, No.49 Huayuan North Road, Haidian District, Beijing, People’s Republic of China, 100191

    Kai-Lun Hu

  2. Zhejiang MedicalTech Therapeutics Company, No.665 Yumeng Road, Wenzhou, People’s Republic of China, 325200

    Kai-Lun Hu, Wenhai Deng, Xiaoxue Li, Liping Ju & Liangshan Mu

  3. Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China, 325000

    Zimiao Chen

  4. Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China, 325000

    Haiyan Yang

  5. Medical Reproductive Center, The Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Gusu District, Suzhou, People’s Republic of China, 215026

    Hong Zhang

Authors
  1. Kai-Lun Hu
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  7. Hong Zhang
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Contributions

KL.H conceived the idea; KL.H and Z.C reviewed the literature and extracted the data; KL.H, X.L and W.D assessed the quality of included studies; KL.H designed the study and wrote the manuscript and designed the figures and tables; H.Z and L.M and H.Y revised the manuscript. All authors participated in the discussion of the analysis and interpretation of data in this article.

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Correspondence to Hong Zhang or Liangshan Mu.

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Hu, KL., Chen, Z., Deng, W. et al. Diagnostic Value of Kisspeptin Levels on Early Pregnancy Outcome: a Systematic Review and Meta-analysis. Reprod. Sci. 29, 3365–3372 (2022). https://doi.org/10.1007/s43032-022-00856-8

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  • DOI: https://doi.org/10.1007/s43032-022-00856-8

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